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The Impact of Birth Weight on Cardiovascular Risk Factors, Coronary Heart Disease and Prostate Cancer: Population-based Studies of Men Born in 1913 and Followed up Until Old Age
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Objectives. To study whether birth weight (BW) was correlated to cardiovascular risk factors, coronary heart disease (CHD), cardiovascular disease (CVD), and prostate cancer (PCA) at adult ages, whether a possible relationship depended on mediating factors from birth time, hereditary circumstances, and adult life variables, and what importance possible associations might have for the rate of the complaint in the general population.

Material and methods. Population-based cohorts of men born in 1913 and followed up until old age. Risk of outcome was estimated using Cox’s and Poisson regressions. The results were transformed to population attributable risk percentage (PAR%) of the complaint that could be attributed to low or high BW, given causality between exposure and outcome.

Results. After adjustment for the influence of covariates, systolic blood pressure at age 50 decreased by 3.7 mmHg per 1000 g increase in BW, the prevalence of antihypertensive treatment decreased by 32%, diabetes by 53%, serum total cholesterol decreased by 0.20 mmol L-1, and being in top quintile of serum cholesterol decreased by 23%. The adjusted risks were somewhat more marked relative to the crude risks. CHD and CVD incidence and mortality were virtually unaffected by BW. In the general population, the risk percentage attributable to a BW ≤3000 g was 18% for diabetes, 2.5% for cholesterol, and ≤1% for antihypertensive treatment and CHD and CVD incidence and mortality.

PCA incidence and mortality risk increased by 62% and 82%, respectively, among those whose BW was ≥4250 g compared with those whose BW was 3001-4249 g. The risk percentages attributable to a BW ≥4250 g in the general population for PCA incidence and mortality were 7.8% and 10.8%.

Conclusions. Low BW seemed to affect cardiovascular risk factors but not incidence and mortality from CHD and CVD. A high proportion of diabetes on the community level could be attributed to low BW, while the proportional burden of other cardiovascular complaints that could be attributed to low BW was modest. PCA incidence and mortality seemed to be affected by high BW.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2005. , p. 74
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 77
Keywords [en]
birth weight, coronary heart disease, cardiovascular disease, diabetes, blood pressure, hypertension, cholesterol, prostate cancer, cohort studies, follow-up studies
National Category
General Practice
Identifiers
URN: urn:nbn:se:uu:diva-6005ISBN: 91-554-6359-2 (print)OAI: oai:DiVA.org:uu-6005DiVA, id: diva2:167072
Public defence
2005-11-03, Rudbecksalen, Rudbecklaboratoriet, Uppsala Science Park, Uppsala, 13:15 (English)
Opponent
Supervisors
Available from: 2005-10-13 Created: 2005-10-13 Last updated: 2018-01-13Bibliographically approved
List of papers
1. Factors associated with birth weight in Sweden: The study of men born in 1913
Open this publication in new window or tab >>Factors associated with birth weight in Sweden: The study of men born in 1913
1997 (English)In: Journal of Epidemiology and Community Health, ISSN 0143-005X, E-ISSN 1470-2738, Vol. 51, no 1, p. 19-23Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-93551 (URN)
Available from: 2005-10-13 Created: 2005-10-13 Last updated: 2017-12-14Bibliographically approved
2. Birth weight and cardiovascular risk factors in a cohort followed until 80 years of age: The study of men born in 1913
Open this publication in new window or tab >>Birth weight and cardiovascular risk factors in a cohort followed until 80 years of age: The study of men born in 1913
Show others...
2004 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 255, p. 236-246Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-93552 (URN)
Available from: 2005-10-13 Created: 2005-10-13 Last updated: 2017-12-14Bibliographically approved
3. The impact of birth weight on coronary heart disease morbidity and mortality in a birth cohort followed up for 85 years: a population-based study of men born in 1913
Open this publication in new window or tab >>The impact of birth weight on coronary heart disease morbidity and mortality in a birth cohort followed up for 85 years: a population-based study of men born in 1913
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2004 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 256, no 6, p. 472-81Article in journal (Refereed) Published
Abstract [en]

Objectives. To analyse whether there is a relationship between birth weight on the one hand and coronary heart disease (CHD) and cardiovascular disease (CVD) mortality and morbidity on the other, whether such a relationship is influenced by potential modifying factors from the time of birth, adult height and the presence of diabetes, and what significance these possible associations might have for the CHD and CVD rates in the general population.

Design. Population-based birth cohort.

Setting. Sweden.

Subjects. A total of 1319 singleton men born in 1913, surviving until age 20 and from then on followed until 85 years of age.

Main outcome measures. CHD and CVD mortality and morbidity events.

Results. The gestational age adjusted CHD and CVD mortality and morbidity hazard ratios were virtually unaffected by birth weight. Taking possible effect-modifying variables into account did not change the results. The population attributable risk percentage for CHD and CVD mortality and morbidity due to a birth weight ≤3000 g was 1% or less.

Conclusions. Birth weight did not significantly affect CHD or CVD mortality or morbidity. A birth weight ≤3000 g contributes little to the burden of CHD and CVD on a community level.

Keywords
adult height, birth weight, cardiovascular disease, coronary heart disease, diabetes
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-93553 (URN)10.1111/j.1365-2796.2004.01412.x (DOI)
Available from: 2005-10-13 Created: 2005-10-13 Last updated: 2017-12-14Bibliographically approved
4. The impact of birth weight on prostate cancer incidence and mortality in a population-based study of men born in 1913 and followed up from 50 to 85 years of age
Open this publication in new window or tab >>The impact of birth weight on prostate cancer incidence and mortality in a population-based study of men born in 1913 and followed up from 50 to 85 years of age
Show others...
2007 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 67, no 11, p. 1247-1254Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Insulin-like growth factor-I (IGF-I) hormone is directly associated with birth weight (BW), and high IGF-I measured in adults is associated with increased risk of prostate cancer (PCA). Whether BW and PCA are related is inconclusive to date. METHODS: BW and PCA incidence and mortality data for a population-based cohort of 1,436 singleton Swedish men born in 1913 and followed until 85 years of age were obtained. RESULTS: BW > or = 4,250 g was associated with significantly higher PCA incidence [62% (CI: 4%-151%)] and PCA mortality [82% (CI: 3%-221%)] than BW 3,001-4,249 g, even when other potential effect modifiers were taken into account. The hazards ratio for PCA incidence fell from approximately 3 at age 50 to unity at age 85. Approximately one out of every six PCA incident cases between 50 and 70 years of age could be attributed to BW > or = 4,250 g. CONCLUSIONS: In the current study PCA incidence and mortality rate appears to increase with BW.

Keywords
Birth weight, Cohort studies, Follow-up studies, Prostate cancer
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-13899 (URN)10.1002/pros.20428 (DOI)000248537500012 ()17570499 (PubMedID)
Available from: 2008-01-28 Created: 2008-01-28 Last updated: 2017-12-11Bibliographically approved

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