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Antioxidant intake, oxidative stress and inflammation among immigrant women from the Middle East living in Sweden: associations with cardiovascular risk factors
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för hushållsvetenskap (IHV).
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
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2007 (Engelska)Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 17, nr 10, s. 748-756Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and aims: Immigrant women from the Middle East have higher cardiovascular risk compared to native women. Whether low antioxidant intake, oxidative stress or inflammation contributes to risk is unknown. In a cross-sectional study of 157 randomly selected foreign-born women (Iranian and Turkish) and native women living in Sweden, we investigated antioxidant status, oxidative stress (F-2-isoprostanes) and systemic inflammation (plasma high sensitive C-reactive protein; CRP) markers. We also investigated relationships between F2-isoprostanes, CRP and cardiovascular risk factors. Methods and result: Dietary intake was assessed using 24-h dietary recalls repeated four times. Micronutrient intake was not consistently different between groups. Serum a-tocopherol, but not gamma-tocopherot levels, was tower in Turkish vs. Swedish women (P < 0.05). Turkish women had the highest F-2-isoprostane levels (P < 0.05 vs. Iranian women) and CRP levels (P < 0.01 vs. Swedish women and P = 0.05 vs. Iranian women). In immigrants (n = 97), F-2-isoprostanes correlated positively to insulin levels (r = 0.31, P < 0.01), and CRP was correlated to obesity and several cardiovascular risk factors (r-values >0.21, P values <0.05). Conclusion: The rote of antioxidant status is unclear, whereas signs of oxidative stress and inflammation are evident in immigrant women from Middle East, especially Turkish women. Oxidative stress and low-grade inflammation might contribute to the higher cardiovascular risk previously observed in immigrant women. Further larger studies adjusting for more potential confounders are motivated to confirm these results.

Ort, förlag, år, upplaga, sidor
2007. Vol. 17, nr 10, s. 748-756
Nyckelord [en]
antioxidant intake, oxidative stress, inflammation, C-reactive protein, isoprostanes, cardiovascular risk factors, immigrants, middle east
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-94763DOI: 10.1016/j.numecd.2006.07.011ISI: 000252460900008PubMedID: 17145175OAI: oai:DiVA.org:uu-94763DiVA, id: diva2:168735
Tillgänglig från: 2006-09-08 Skapad: 2006-09-08 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
Ingår i avhandling
1. Diet and Metabolic Risk Factors in Immigrant Women from the Middle East and Swedish-Born Women: A Cross-Sectional Study of Women from Iran, Turkey and Sweden
Öppna denna publikation i ny flik eller fönster >>Diet and Metabolic Risk Factors in Immigrant Women from the Middle East and Swedish-Born Women: A Cross-Sectional Study of Women from Iran, Turkey and Sweden
2006 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The increasing number of immigrants in Sweden during the past decades has brought the health of different ethnic groups into focus. Many groups of immigrants in Sweden have a higher risk of cardiovascular disease (CVD) and coronary heart disease (CHD) than a Swedish reference group. The objective of this thesis was to study the health status and prevalence of metabolic risk factors among immigrant women from Iran and Turkey in comparison with native-Swedish women. The analyses are based on a cross-sectional study of first-generation immigrant women and women born in Sweden aged 35-64. The women underwent a clinical examination, including blood sampling and anthropometric measurements. Dietary intake was assessed by four repeated 24-hour food intake recalls.

The results show important ethnic differences in risk factors for CHD and the metabolic syndrome between the immigrant and the Swedish-born women. Immigrant women from Iran and Turkey are heavier, with a higher prevalence of abdominal obesity and an unfavourable lipid profile and a high degree of physical inactivity during leisure-time, which may predispose for a higher incidence of diabetes and atherosclerotic CVD. The associations between dietary variables and metabolic risk factors were generally relatively weak. The degree of underreporting of the energy was significant, especially among immigrant women, which might have attenuated possible associations. The fatty acid profile of the diet and in serum among the immigrant women indicated both favourable and unfavourable features, despite a higher prevalence of obesity and dyslipidemia compared to the Swedish-born women. Signs of oxidative stress and inflammation are evident in the immigrant women from the Middle East.

With reference to ethnical differences in metabolic risk factors, as demonstrated in this thesis, increased emphasis should be given to modifying the underlying factors such as overweight/obesity and physical inactivity associated with the metabolic syndrome in various immigrant groups.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2006. s. 70
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences, ISSN 1652-9030 ; 15
Nyckelord
Caring sciences, cardiovascular factors, metabolic risk factors, immigrants, Iranian, Turkish, Swedish, Middle East, dietary intake, underreporting, dietary fat, fat sources, antioxidant intake, oxidative stress, inflammation, C-reactive protein, isoprostanes, Vårdvetenskap
Identifikatorer
urn:nbn:se:uu:diva-7103 (URN)91-554-6631-1 (ISBN)
Disputation
2006-09-29, Maria salen, Stiftets Hus, Dragarbrunsgatan 71, Uppsala, 09:15
Opponent
Handledare
Tillgänglig från: 2006-09-08 Skapad: 2006-09-08Bibliografiskt granskad

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Institutionen för folkhälso- och vårdvetenskapInstitutionen för hushållsvetenskap (IHV)Klinisk kemi
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NMCD. Nutrition Metabolism and Cardiovascular Diseases
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