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Prevalence of open-angle glaucoma in Central Sweden: The Tierp Glaucoma Survey
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Socialmedicin.ORCID-id: 0000-0002-8265-6518
1996 (Engelska)Ingår i: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 74, nr 2, s. 107-112Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In 1984‐86, a glaucoma survey was carried out in a municipality in central Sweden, comprising 760 subjects 65–74 years of age. Since 1988, a follow‐up study of those 527 subjects who had normal and reliable visual fields has been in progress. A visual field defect was required for a diagnosis of chronic open‐angle glaucoma. By December 1991, 10 cases of capsular glaucoma and 3 cases of chronic simple glaucoma had been found. The standardized relative risk for chronic open‐angle glaucoma was 3.4 times (95% confidence interval: 1.1 ‐ 11) greater in subjects with a baseline intraocular pressure < 21 mmHg, using the highest pressure in either eye, than in those with an intraocular pressure < 21 mmHg. Pseudoexfoliation increased the standardized relative risk 9.8‐fold (95% confidence interval: 2.5 – 38). There was indication of effect modification between intraocular pressure and pseudoexfoliation. Optic disc haemorrhages were associated with a 4.8‐fold (95% confidence interval: 0.63 – 37) increased unadjusted risk. The study supports the pressure theory of optic nerve damage in glaucoma. Pseudoexfoliation was recognized as an independent risk factor for the development of chronic open‐angle glaucoma.

Ort, förlag, år, upplaga, sidor
1996. Vol. 74, nr 2, s. 107-112
Nationell ämneskategori
Oftalmologi
Identifikatorer
URN: urn:nbn:se:uu:diva-96476DOI: 10.1111/j.1600-0420.1996.tb00052.xPubMedID: 8739672OAI: oai:DiVA.org:uu-96476DiVA, id: diva2:171062
Tillgänglig från: 2007-11-22 Skapad: 2007-11-22 Senast uppdaterad: 2019-10-25Bibliografiskt granskad
Ingår i avhandling
1. Studies on the Epidemiology of Open-angle Glaucoma
Öppna denna publikation i ny flik eller fönster >>Studies on the Epidemiology of Open-angle Glaucoma
2007 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Glaucoma is a common disease in the elderly population. Open-angle glaucoma (OAG) is the predominant form of glaucoma. Chronic simple glaucoma and capsular glaucoma, characterized by the occurrence of pseudoexfoliation in the anterior eye segment, are the most frequent types of OAG. The purpose of the present thesis was to study the epidemiology of OAG in the municipality of Tierp, whose population has a high exposure to pseudoexfoliation.

In a case-finding study, the prevalence of known cases of OAG by December 31, 1983 was estimated to 1.4% in people ≥45 years of age. Sixty-three percent of all cases had capsular glaucoma. Patients with advanced glaucoma were older, had had the disease for longer, had higher mean initial intraocular pressure, and had more extensive visual field defects at the time of diagnosis.

A population survey of people 65–74 years of age was conducted in 1984–86. The prevalence of OAG was 5.3%. Pseudoexfoliation was found in 17%, being more common in females. Pseudoexfoliation was associated with OAG only in people previously diagnosed with the disease (odds ratio = 16). In cases detected at the survey, an intraocular pressure ≥20 mmHg was a serious risk factor of having OAG (odds ratio = 9.7).

In a 5-year follow-up study of participants in the population survey, increased intraocular pressure and pseudoexfoliation were recognized as independent risk factors for the development of OAG (standardized risk ratios = 3.4 and 9.8, respectively). Interaction between increased intraocular pressure and pseudoexfoliation was indicated. By May 2006, the incidence of OAG was estimated to 7.1 per 1,000 person-years. The incidence of capsular glaucoma was more than twice that of chronic simple glaucoma.

The prevalence and incidence of OAG was higher than that reported from other studies conducted on Caucasian populations. The probable explanation for this finding is exposure to pseudoexfoliation.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2007. s. 60
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 294
Nyckelord
Ophtalmology, Open-angle glaucoma, Epidemiology, Capsular glaucoma, Chronic simple glaucoma, Normal tension glaucoma, Pseudoexfoliation, Pseudoexfoliation glaucoma, Prevalence, Incidence, Intraocular pressure, Oftalmiatrik
Identifikatorer
urn:nbn:se:uu:diva-8323 (URN)978-91-554-7032-6 (ISBN)
Disputation
2007-12-13, Enghoffsalen, Ingång 50, Akademiska sjukhuset, 751 85 Uppsala, 13:15
Opponent
Handledare
Tillgänglig från: 2007-11-22 Skapad: 2007-11-22Bibliografiskt granskad

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