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Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape
Queen Mary Univ, Blizard Inst, Barts & London Sch Med & Dent, London, England..ORCID iD: 0000-0002-5629-5026
Queen Mary Univ, Blizard Inst, Barts & London Sch Med & Dent, London, England..
Vrije Univ Brussel, Lab Mol & Cellular Therapy, Brussels, Belgium..
Queen Mary Univ, Blizard Inst, Barts & London Sch Med & Dent, London, England..
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2022 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 11, article id e77335Article in journal (Refereed) Published
Abstract [en]

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identification of enriched predicted binding sites of transcription factors known to cause demethylation and to be involved in astrocytic/glial lineage specification, point to a shared ontogeny between these glioblastomas and astroglial progenitors. At functional level, increased invasiveness, at least in part mediated by SRPX2, and macrophage infiltration characterise this subset of glioblastoma.

Place, publisher, year, edition, pages
eLIFE SCIENCES PUBL LTD eLife Sciences Publications Ltd, 2022. Vol. 11, article id e77335
Keywords [en]
glioblastoma, astrocytes, DNA methylation, Human, Mouse
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-490737DOI: 10.7554/eLife.77335ISI: 000889344600001PubMedID: 36412091OAI: oai:DiVA.org:uu-490737DiVA, id: diva2:1719454
Available from: 2022-12-15 Created: 2022-12-15 Last updated: 2024-01-15Bibliographically approved

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Nelander, Sven

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