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Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.ORCID iD: 0000-0002-4566-5079
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0002-7142-3479
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.ORCID iD: 0000-0002-8925-9670
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.ORCID iD: 0000-0002-8258-8703
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2023 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 23, no 1, p. 59-65Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Neuropeptide Y is associated with stress in animal and human laboratory studies. However, data from clinical studies are scarce and no clinical longitudinal studies have been published. The aim of this clinical study was to assess the possible association between changes in the levels of pain, depression, and stress measures, on the one hand, and plasma neuropeptide Y levels, on the other.

METHODS: Forty-four women with the fibromyalgia syndrome were exposed to a Cognitive Behavioral Therapy intervention. Levels of the plasma neuropeptide Y as well as pain, depression, and stress measures were obtained at the start and at the end of the intervention, and after a further six month follow-up. Based on these data, a before-and-after analysis was performed.

RESULTS: Almost all measures of pain, depression, and stress improved during the study; specifically, variables measuring life control (coping), depression, and stress-related time urgency improved significantly. Moreover, during the same time period, the mean plasma neuropeptide Y level was reduced from 93.2 ± 38.8 fmol/mL before the Cognitive Behavioral Therapy to 75.6 ± 42.9 fmol/mL (p<0.001) at the end of the study.

CONCLUSIONS: After exposure to a Cognitive Behavioral Therapy intervention, levels of most of the pain, depression, and stress measures improved, half of them significantly, as did the levels of neuropeptide Y. This circumstance indicates a possible functional relationship between pain-depression-stress and neuropeptide Y.

Place, publisher, year, edition, pages
Walter de Gruyter, 2023. Vol. 23, no 1, p. 59-65
Keywords [en]
depression, fibromyalgia, pain, plasma neuropeptide Y, stress, women
National Category
Applied Psychology General Practice
Identifiers
URN: urn:nbn:se:uu:diva-494265DOI: 10.1515/sjpain-2022-0016ISI: 000814052400001PubMedID: 35728621OAI: oai:DiVA.org:uu-494265DiVA, id: diva2:1727546
Funder
Swedish Research Council, 9459Stiftelsen Söderström - Königska sjukhemmet, 2003-139Swedish Rheumatism Association, 51/04Uppsala University, UVF 2003/39Swedish Social Insurance Agency, 9459Available from: 2023-01-16 Created: 2023-01-16 Last updated: 2024-01-11Bibliographically approved

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Karlsson, BoNyberg, FredSvärdsudd, KurtBurell, GunillaBjörkegren, KarinKristiansson, Per

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