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Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee
Scripps Res Inst, Dept Mol Med, Protego Biopharm San Diego, La Jolla, CA USA..
Mayo Clin, Div Hematol, Rochester, MN USA..
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA USA..
Ulm Univ, Inst Prot Biochem, Ulm, Germany..
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2022 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 29, no 4, p. 213-219Article in journal (Refereed) Published
Abstract [en]

The Nomenclature Committee of the International Society of Amyloidosis met at the XVIII International Symposium on Amyloidosis in September and virtually in October 2022 with discussions resulting in this upgraded nomenclature recommendation. The nomenclature principles remain unchanged but there is an ongoing discussion regarding the importance and varying nature of intracellular protein aggregates, particularly those associated with neurodegenerative diseases. Six novel proteins were added to the list of human amyloid fibril proteins. Of these, three are polypeptide hormones and two currently utilised peptide drugs, making the number of known iatrogenic amyloid forms four, all appearing as subcutaneous nodules at the injection site. The sixth novel amyloid fibril protein is the transmembrane 106B protein, forming intracellular amyloid fibrils in disorders associated with frontotemporal dementia. The number of known human amyloid fibril proteins is now 42.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2022. Vol. 29, no 4, p. 213-219
Keywords [en]
Fibril, amyloid protein, nomenclature, intracellular aggregate, functional
National Category
Biochemistry and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-497012DOI: 10.1080/13506129.2022.2147636ISI: 000890933200001PubMedID: 36420821OAI: oai:DiVA.org:uu-497012DiVA, id: diva2:1739105
Available from: 2023-02-23 Created: 2023-02-23 Last updated: 2023-02-23Bibliographically approved

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Westermark, Per

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Neurooncology and neurodegeneration
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Amyloid: Journal of Protein Folding Disorders
Biochemistry and Molecular BiologyMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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