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The Journey of Cancer Cells to the Brain: Challenges and Opportunities
Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Genom, Postepu 36A, PL-05552 Garbatka, Poland..
Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Genom, Postepu 36A, PL-05552 Garbatka, Poland..ORCID iD: 0000-0002-4186-4900
Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Genom, Postepu 36A, PL-05552 Garbatka, Poland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neurooncology and neurodegeneration. Karolinska Inst, Dept Lab Med, Div Pathol, SE-14186 Stockholm, Sweden.ORCID iD: 0000-0002-8050-6516
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2023 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 24, no 4, article id 3854Article, review/survey (Refereed) Published
Abstract [en]

Cancer metastases into the brain constitute one of the most severe, but not uncommon, manifestations of cancer progression. Several factors control how cancer cells interact with the brain to establish metastasis. These factors include mediators of signaling pathways participating in migration, infiltration of the blood-brain barrier, interaction with host cells (e.g., neurons, astrocytes), and the immune system. Development of novel therapies offers a glimpse of hope for increasing the diminutive life expectancy currently forecasted for patients suffering from brain metastasis. However, applying these treatment strategies has not been sufficiently effective. Therefore, there is a need for a better understanding of the metastasis process to uncover novel therapeutic targets. In this review, we follow the journey of various cancer cells from their primary location through the diverse processes that they undergo to colonize the brain. These processes include EMT, intravasation, extravasation, and infiltration of the blood-brain barrier, ending up with colonization and angiogenesis. In each phase, we focus on the pathways engaging molecules that potentially could be drug target candidates.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 24, no 4, article id 3854
Keywords [en]
brain, metastasis, cancer, immune cells
National Category
Cancer and Oncology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-500098DOI: 10.3390/ijms24043854ISI: 000945051900001PubMedID: 36835266OAI: oai:DiVA.org:uu-500098DiVA, id: diva2:1750032
Available from: 2023-04-12 Created: 2023-04-12 Last updated: 2023-04-12Bibliographically approved

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Kurzejamska, Ewa

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