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Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake
Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden..ORCID iD: 0000-0001-9752-8917
Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden..ORCID iD: 0000-0003-2706-9502
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neurooncology and neurodegeneration. Uppsala University, Science for Life Laboratory, SciLifeLab. Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiophys, Lund, Sweden..ORCID iD: 0000-0003-1585-5434
2023 (English)In: American Journal of Physiology - Cell Physiology, ISSN 0363-6143, E-ISSN 1522-1563, Vol. 324, no 1, p. C76-C84Article, review/survey (Refereed) Published
Abstract [en]

As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understudied. Here we compile some of the latest studies focusing on HSPGs as internalizing receptors of extracellular vesicles ("endogenous virus") and SARS-CoV-2 lipid-enclosed particles and highlight similarities in their biophysical and structural characteristics. Specifically, the similarities in their biogenesis, size, and lipid composition may explain a common dependence on HSPGs for efficient cell-surface attachment and uptake. We further discuss the relative complexity of extracellular vesicle composition and the viral mechanisms that evolve towards increased infectivity that complicate therapeutic strategies addressing blockade of their uptake.

Place, publisher, year, edition, pages
AMERICAN PHYSIOLOGICAL SOCIEY American Physiological Society, 2023. Vol. 324, no 1, p. C76-C84
Keywords [en]
cancer, COVID-19, extracellular vesicles, proteoglycans, SARS-CoV-2
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-500413DOI: 10.1152/ajpcell.00453.2022ISI: 000957546100008PubMedID: 36458979OAI: oai:DiVA.org:uu-500413DiVA, id: diva2:1751315
Funder
Swedish Research Council, VR-MH 2018-02562Swedish Cancer Society, CAN 20 0745 PjFSwedish Childhood Cancer Foundation, PR2020-0129Mrs. Berta Kamprad's Cancer FoundationSjöberg FoundationAvailable from: 2023-04-17 Created: 2023-04-17 Last updated: 2024-01-15Bibliographically approved

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Belting, Mattias

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Neurooncology and neurodegenerationScience for Life Laboratory, SciLifeLab
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