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Endogenous incretin levels and risk of first incident cancer: a prospective cohort study
Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden.;Skane Univ Hosp, Dept Cardiol, Malmö, Sweden.;Lund Univ, Lund Univ Diabet Ctr, Dept Clin Sci, Malmö, Sweden.;Lund Univ, Clin Res Ctr, Box 50332, S-20213 Malmö, Sweden..
Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden..ORCID iD: 0000-0003-1501-0458
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neurooncology and neurodegeneration. Uppsala University, Science for Life Laboratory, SciLifeLab. Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden..ORCID iD: 0000-0003-1585-5434
Lund Univ, Lund Univ Diabet Ctr, Dept Clin Sci, Malmö, Sweden..
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2023 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 13, article id 382Article in journal (Refereed) Published
Abstract [en]

Concerns have been raised regarding a potentially increased risk of cancer associated with treatment with glucagon-like peptide-1 (GLP-1) receptor agonists. Here, we explored whether fasting and oral glucose tolerance test post-challenge glucose-dependent insulinotropic peptide (GIP) and GLP-1 levels were associated with incident first cancer. Within the cardiovascular re-examination arm of the population-based Malmo Diet Cancer study (n = 3734), 685 participants with a previous cancer diagnosis were excluded, resulting in 3049 participants (mean age 72.2 +/- 5.6 years, 59.5% women), of whom 485 were diagnosed with incident first cancer (median follow-up time 9.9 years). Multivariable Cox-regression and competing risk regression (death as competing risk) were used to explore associations between incretin levels and incident first cancer. Higher levels of fasting GLP-1 (462 incident first cancer cases/2417 controls) showed lower risk of incident first cancer in competing risk regression (sub-hazard ratio 0.90; 95% confidence interval 0.82-0.99; p = 0.022). No association was seen for fasting GIP, post-challenge GIP, or post-challenge GLP-1 and incident first cancer. In this prospective study, none of the fasting and post-challenge levels of GIP and GLP-1 were associated with higher risk of incident first cancer; by contrast, higher levels of fasting GLP-1 were associated with lower risk of incident first cancer.

Place, publisher, year, edition, pages
Springer Nature, 2023. Vol. 13, article id 382
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Endocrinology and Diabetes Cancer and Oncology
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URN: urn:nbn:se:uu:diva-503658DOI: 10.1038/s41598-023-27509-3ISI: 000984279900030PubMedID: 36611045OAI: oai:DiVA.org:uu-503658DiVA, id: diva2:1765153
Available from: 2023-06-09 Created: 2023-06-09 Last updated: 2023-06-09Bibliographically approved

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Belting, Mattias

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