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Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm Infants before 32 Weeks of Gestation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.ORCID iD: 0000-0001-5955-1278
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2023 (English)In: Nutrients, E-ISSN 2072-6643, Vol. 15, no 12, article id 2818Article in journal (Refereed) Published
Abstract [en]

Breast milk (BM) is the primary nutrition for infants and has a high content of lipids. Preterm infants receive expressed BM via tube feeding, and they are frequently treated with phototherapy. When parenteral nutrition (PN) is exposed to light and/or phototherapy, lipid peroxidation (LPO) increases. By light-protecting PN, morbidity and mortality are reduced in preterm infants through the reduction of oxidative stress. We aimed to investigate whether light-protecting breast milk could reduce LPO. Twelve mothers giving birth to a preterm infants of less than 32 weeks of gestational age were included. Transitional BM was collected and divided into three study groups; light-protected, ward light and phototherapy light. Baseline samples were collected after expression and the exposures started within one hour. Feeding syringe samples were exposed to light for 30 up to 360 min. Nasogastric tube samples were run through a tube under the same light conditions. Samples were stored in -80 °C until analyses of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) and total antioxidant capacity (TAC). There were no significant differences in MDA, 4-HNE or TAC levels observed between the different study groups. This study indicates that the light exposure of expressed transitional BM does not affect LPO and the levels of MDA, 4-HNE or TAC.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 15, no 12, article id 2818
Keywords [en]
4-hydroxynonenal, enteral nutrition, human breast milk, light protection, lipid peroxidation, malondialdehyde, naso-gastric tube feeding, phototherapy, preterm infants, total antioxidant capacity
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Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-507422DOI: 10.3390/nu15122818ISI: 001014786100001PubMedID: 37375721OAI: oai:DiVA.org:uu-507422DiVA, id: diva2:1780576
Available from: 2023-07-06 Created: 2023-07-06 Last updated: 2023-08-28Bibliographically approved

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Latheef, FaizaThernström Blomqvist, YlvaLarsson, AndersPaulsson, MattiasDiderholm, Barbro

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