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Predictive biomarkers in radioresistant rectal cancer: A systematic review
Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;Dept Oncol, Hobrovej 18-22, DK-9000 Aalborg, Denmark..ORCID iD: 0000-0001-7773-2494
Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark..
Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark..ORCID iD: 0000-0002-9245-7678
Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;Aalborg Univ Hosp, Dept Hematol, Aalborg, Denmark..ORCID iD: 0000-0003-2488-435X
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2023 (English)In: Critical reviews in oncology/hematology, ISSN 1040-8428, E-ISSN 1879-0461, Vol. 186, article id 103991Article, review/survey (Refereed) Published
Abstract [en]

Background and aims

The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer.

Method

Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results.

Results

Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 186, article id 103991
Keywords [en]
Rectal Neoplasms, Neoadjuvant therapy, Radiotherapy, Molecular biomarker, Resistance
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-509307DOI: 10.1016/j.critrevonc.2023.103991ISI: 001040298800001PubMedID: 37059272OAI: oai:DiVA.org:uu-509307DiVA, id: diva2:1789038
Available from: 2023-08-17 Created: 2023-08-17 Last updated: 2023-08-17Bibliographically approved

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Belting, Mattias

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