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Association of Sarcopenia and Its Defining Components with the Degree of Cognitive Impairment in a Memory Clinic Population
Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Swedish Sch Sport & Hlth Sci, GIH, Stockholm, Sweden..
Swedish Sch Sport & Hlth Sci, GIH, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.;Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism. Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden..ORCID iD: 0000-0003-3705-0725
Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden..
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2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 96, no 2, p. 777-788Article in journal (Refereed) Published
Abstract [en]

Background: Sarcopenia and cognitive impairment are two leading causes of disabilities. Objective: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.

Methods: 368 patients were included (age 59.0 +/- 7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer's disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0-3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.

Results: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06-0.90) and AD (OR: 0.12, 95% CI: 0.03-0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45-11.92).

Conclusions: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigations are required to further verify the causal relationship between sarcopenia and cognitive outcomes.

Place, publisher, year, edition, pages
IOS Press, 2023. Vol. 96, no 2, p. 777-788
Keywords [en]
Alzheimer's disease, body composition, cognitive function, gait speed, hand grip strength, outpatients, sarcopenia
National Category
Geriatrics Neurology
Identifiers
URN: urn:nbn:se:uu:diva-518790DOI: 10.3233/JAD-221186ISI: 001099536400028PubMedID: 37899056OAI: oai:DiVA.org:uu-518790DiVA, id: diva2:1823288
Funder
Swedish Research Council, 2022-01404Knowledge Foundation, 2018-0151Knowledge Foundation, 2021-0002Knowledge Foundation, 2022-0202Karolinska InstituteAlzheimerfondenRegion StockholmKnut and Alice Wallenberg FoundationKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseAvailable from: 2024-01-02 Created: 2024-01-02 Last updated: 2024-01-02Bibliographically approved

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Cederholm, Tommy

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