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Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.ORCID iD: 0000-0002-3268-8810
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-4074-7235
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-5833-0040
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2024 (English)In: Eur J Epidemiol, ISSN 1573-7284 Electronic 0393-2990 LinkingArticle in journal (Refereed) Published
Abstract [en]

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Place, publisher, year, edition, pages
2024.
Keywords [en]
Atherosclerosis Coronary heart disease Emphysema Spirometry
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Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-520136DOI: 10.1007/s10654-023-01088-zOAI: oai:DiVA.org:uu-520136DiVA, id: diva2:1826440
Note

Engstrom, Gunnar Lampa, Erik Dekkers, Koen Lin, Yi-Ting Ahlm, Kristin Ahlstrom, Hakan Alfredsson, Joakim Bergstrom, Goran Blomberg, Anders Brandberg, John Caidahl, Kenneth Cederlund, Kerstin Duvernoy, Olov Engvall, Jan E Eriksson, Maria J Fall, Tove Gigante, Bruna Gummesson, Anders Hagstrom, Emil Hamrefors, Viktor Hedner, Jan Janzon, Magnus Jernberg, Tomas Johnson, Linda Lind, Lars Lindberg, Eva Mannila, Maria Nilsson, Ulf Persson, Anders Persson, Hans Lennart Persson, Margaretha Ramnemark, Anna Rosengren, Annika Schmidt, Caroline Skoglund Larsson, Linn Skold, C Magnus Swahn, Eva Soderberg, Stefan Toren, Kjell Waldenstrom, Anders Wollmer, Per Zaigham, Suneela Ostgren, Carl Johan Sundstrom, Johan eng ERC-2018-STG-801965/ERC_/European Research Council/International Netherlands 2024/01/02 Eur J Epidemiol. 2024 Jan 2. doi: 10.1007/s10654-023-01088-z.

Available from: 2024-01-11 Created: 2024-01-11 Last updated: 2024-01-11

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Publisher's full texthttps://www.ncbi.nlm.nih.gov/pubmed/38165527

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Lampa, ErikDekkers, KoenLin, Yi-TingAhlström, HåkanDuvernoy, OlovFall, ToveHagström, EmilLind, LarsLindberg, EvaZaigham, SuneelaSundström, Johan

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Lampa, ErikDekkers, KoenLin, Yi-TingAhlström, HåkanDuvernoy, OlovFall, ToveHagström, EmilLind, LarsLindberg, EvaZaigham, SuneelaSundström, Johan
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Clinical EpidemiologyMolecular epidemiologyScience for Life Laboratory, SciLifeLabRadiologyCardiologyUppsala Clinical Research Center (UCR)Centre for Research and Development, GävleborgClinical Nutrition and MetabolismLung- allergy- and sleep researchClinical PhysiologyDepartment of Public Health and Caring SciencesOccupational and Environmental Medicine
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CiteExportLink to record
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