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Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.ORCID iD: 0000-0003-3962-3953
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.ORCID iD: 0000-0002-1181-6262
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2024 (English)In: EBioMedicine, E-ISSN 2352-3964, Vol. 100, article id 104989Article in journal (Refereed) Published
Abstract [en]

Background

Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from the Swedish CArdioPulmonary bioImage Study.

Methods

In 8416 participants aged 50–65, time in SED, MPA, and VPA were estimated with hip-worn accelerometer. Gut microbiota was profiled using shotgun metagenomics of faecal samples. We applied multivariable regression models, adjusting for sociodemographic, lifestyle, and technical covariates, and accounted for multiple testing.

Findings

Overall, associations between time in SED and microbiota species abundance were in opposite direction to those for MPA or VPA. For example, MPA was associated with lower, while SED with higher abundance of Escherichia coli. MPA and VPA were associated with higher abundance of the butyrate-producers Faecalibacterium prausnitzii and Roseburia spp. We observed discrepancies between specific VPA and MPA associations, such as a positive association between MPA and Prevotella copri, while no association was detected for VPA. Additionally, SED, MPA and VPA were associated with the functional potential of the microbiome. For instance, MPA was associated with higher capacity for acetate synthesis and SED with lower carbohydrate degradation capacity.

Interpretation

Our findings suggest that sedentary and physical activity are associated with a similar set of gut microbiota species but in opposite directions. Furthermore, the intensity of physical activity may have specific effects on certain gut microbiota species.

Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 100, article id 104989
Keywords [en]
Accelerometery, Gastrointestinal microbiome, Exercise, Sedentary behaviour, Epidemiology
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-522177DOI: 10.1016/j.ebiom.2024.104989ISI: 001180180700001PubMedID: 38301483OAI: oai:DiVA.org:uu-522177DiVA, id: diva2:1833677
Available from: 2024-02-01 Created: 2024-02-01 Last updated: 2024-04-09Bibliographically approved

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Baldanzi, GabrielSayols-Baixeras, SergiDekkers, Koen F.Hammar, UlfNguyen, DiemAhmad, ShafqatJohansson, Peter J.Lind, LarsKennedy, BeatriceFall, Tove

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Baldanzi, GabrielSayols-Baixeras, SergiDekkers, Koen F.Hammar, UlfNguyen, DiemAhmad, ShafqatJohansson, Peter J.Lind, LarsKennedy, BeatriceFall, Tove
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