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Caveolin-1 genotypes as predictor for locoregional recurrence and contralateral disease in breast cancer
Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden..ORCID iD: 0000-0003-1501-0458
Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Malmö, Sweden..
Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Malmö, Sweden..
Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden.;Aarhus Univ, Dept Oncol, Aarhus, Denmark.;Aarhus Univ Hosp, Aarhus, Denmark..ORCID iD: 0000-0001-7938-8893
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2023 (English)In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 199, no 2, p. 335-347Article in journal (Refereed) Published
Abstract [en]

Purpose

Caveolin-1 (CAV1) has been implicated in breast cancer oncogenesis and metastasis and may be a potential prognosticator, especially for non-distant events. CAV1 functions as a master regulator of membrane transport and cell signaling. Several CAV1 SNPs have been linked to multiple cancers, but the prognostic impact of CAV1 SNPs in breast cancer remains unclear. Here, we investigated CAV1 polymorphisms in relation to clinical outcomes in breast cancer.

Methods

A cohort of 1017 breast cancer patients (inclusion 2002–2012, Sweden) were genotyped using Oncoarray by Ilumina. Patients were followed for up to 15 years. Five out of six CAV1 SNPs (rs10256914, rs959173, rs3807989, rs3815412, and rs8713) passed quality control and were used for haplotype construction. CAV1 genotypes and haplotypes in relation to clinical outcomes were assessed with Cox regression and adjusted for potential confounders (age, tumor characteristics, and adjuvant treatments).

Results

Only one SNP was associated with lymph node status, no other SNPs or haplotypes were associated with tumor characteristics. The CAV1 rs3815412 CC genotype (5.8% of patients) was associated with increased risk of contralateral breast cancer, adjusted hazard ratio (HRadj) 4.26 (95% CI 1.86–9.73). Moreover, the TTACA haplotype (13% of patients) conferred an increased risk for locoregional recurrence HRadj 2.24 (95% CI 1.24–4.04). No other genotypes or haplotypes were associated with clinical outcome.

Conclusion

CAV1 polymorphisms were associated with increased risk for locoregional recurrence and contralateral breast cancer. These findings may identify patients that could derive benefit from more tailored treatment to prevent non-distant events, if confirmed.

Place, publisher, year, edition, pages
Springer, 2023. Vol. 199, no 2, p. 335-347
Keywords [en]
Caveolin-1, Genotype, Locoregional breast cancer recurrence, Contralateral breast cancer
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-523246DOI: 10.1007/s10549-023-06919-xISI: 000963684800002PubMedID: 37017811OAI: oai:DiVA.org:uu-523246DiVA, id: diva2:1838526
Funder
Swedish Cancer Society, CAN 20 0763Lund UniversityMrs. Berta Kamprad's Cancer FoundationRegion Skåne, 40620Available from: 2024-02-16 Created: 2024-02-16 Last updated: 2024-02-16Bibliographically approved

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Belting, Mattias

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