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Genetic and clinical study of myeloperoxidase's association with coronary artery disease
Univ Zakho, Coll Sci, Dept Biol, Duhok, Kurdistan Regio, Iraq..
Univ Nawroz, Coll Sci, Dept Biol, Duhok, Kurdistan Regio, Iraq..
Univ Duhok, Coll Med, Dept Cardiothorac & Vasc Surg, Duhok, Kurdistan Regio, Iraq..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Salahaddin Univ Erbil, Coll Sci, Dept Biol, Erbil, Kurdistan Regio, Iraq..ORCID iD: 0000-0002-9552-838X
2024 (English)In: EGYPTIAN HEART JOURNAL, ISSN 1110-2608, Vol. 76, no 1, article id 27Article in journal (Refereed) Published
Abstract [en]

BackgroundUnraveling myeloperoxidase's (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies.ResultsCAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphatase, creatinine, and troponin levels, showed significant variations. Moreover, CAD patients had lower red cell distribution width (RDW%) and mean platelet volume (MPV) than controls. Serum MPO levels did not differ significantly between CAD patients and controls, and no correlation was found with other clinical parameters except for glucose, creatinine, and total bilirubin.ConclusionsThe data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD.Trial registration: 15092021-9-12. Registered 15 September 2021.ConclusionsThe data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD.Trial registration: 15092021-9-12. Registered 15 September 2021.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 76, no 1, article id 27
Keywords [en]
Myeloperoxidase (MPO), Coronary artery disease (CAD), Biomarkers, Cardiovascular risk, Genetic variation
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-525051DOI: 10.1186/s43044-024-00457-7ISI: 001168431400004PubMedID: 38383869OAI: oai:DiVA.org:uu-525051DiVA, id: diva2:1844924
Available from: 2024-03-15 Created: 2024-03-15 Last updated: 2024-03-15Bibliographically approved

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Shekha, Mudhir S.

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