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The Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)
Univ Melbourne, Melbourne Med Sch, Dept Med, Western Hlth, Melbourne, Vic, Australia.;Univ Melbourne, Australian Inst Musculoskeletal Sci AIMSS, Melbourne, Vic, Australia.;Western Hlth, Melbourne, Vic, Australia..ORCID iD: 0000-0002-0176-776X
Calif Pacific Med Ctr, Res Inst, 550 16th St,Second Floor, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA..
Natl Ctr Geriatr & Gerontol, Obu, Aichi, Japan..
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Geriatr, Mexico City, Mexico.;Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, UMR 1219, Inserm, F-33000 Bordeaux, France..
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2024 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 53, no 3, article id afae052Article in journal (Refereed) Published
Abstract [en]

Importance Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists. Objective The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing the global conceptual definition of sarcopenia. Design The GLIS steering committee was formed in 2019-21 with representatives from all relevant scientific societies worldwide. During this time, the steering committee developed a set of statements on the topic and invited members from these societies to participate in a two-phase International Delphi Study. Between 2022 and 2023, participants ranked their agreement with a set of statements using an online survey tool (SurveyMonkey). Statements were categorised based on predefined thresholds: strong agreement (>80%), moderate agreement (70-80%) and low agreement (<70%). Statements with strong agreement were accepted, statements with low agreement were rejected and those with moderate agreement were reintroduced until consensus was reached. Results 107 participants (mean age: 54 +/- 12 years [1 missing age], 64% men) from 29 countries across 7 continents/regions completed the Delphi survey. Twenty statements were found to have a strong agreement. These included; 6 statements on 'general aspects of sarcopenia' (strongest agreement: the prevalence of sarcopenia increases with age (98.3%)), 3 statements on 'components of sarcopenia' (muscle mass (89.4%), muscle strength (93.1%) and muscle-specific strength (80.8%) should all be a part of the conceptual definition of sarcopenia)) and 11 statements on 'outcomes of sarcopenia' (strongest agreement: sarcopenia increases the risk of impaired physical performance (97.9%)). A key finding of the Delphi survey was that muscle mass, muscle strength and muscle-specific strength were all accepted as 'components of sarcopenia', whereas impaired physical performance was accepted as an 'outcome' rather than a 'component' of sarcopenia. Conclusion and relevance The GLIS has created the first global conceptual definition of sarcopenia, which will now serve to develop an operational definition for clinical and research settings.

Place, publisher, year, edition, pages
Oxford University Press, 2024. Vol. 53, no 3, article id afae052
Keywords [en]
older people, conceptual, definitions, sarcopenia, GLIS
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:uu:diva-526386DOI: 10.1093/ageing/afae052ISI: 001190159300001PubMedID: 38520141OAI: oai:DiVA.org:uu-526386DiVA, id: diva2:1851265
Available from: 2024-04-12 Created: 2024-04-12 Last updated: 2024-04-12Bibliographically approved

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Cederholm, Tommy

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