uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Associations between short sleep duration and central obesity in women
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Medicin.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lungmedicin och allergologi.
Umeå universitet, Insitutionen för lungmedicin.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 33, nr 5, s. 593-598Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Central obesity is closely related to morbidity. Finding potentially modifiable risk factors is important. The aim was to assess associations between sleep duration and central obesity in women. Methods: A population-based, cross-sectional sample of 400 women (range 20-70 years) in Uppsala, Sweden was investigated by full-night polysomnography and measurement of anthropometric variables. Results: Sleep duration was inversely related to both waist circumference and sagittal abdominal diameter. A mean difference of 9 cm in waist circumference (p<0.0001) and 3 cm in sagittal abdominal diameter (p<0.0001) was observed between women sleeping <5 hours and women sleeping ≥8 hours. Sleep duration remained inversely related to waist circumference (adj. β= -1.22 cm/h; p=0.0023) and sagittal abdominal diameter (adj. β= -0.46 cm/h; p=0.001) after adjusting for potential confounders. Duration of slow-wave sleep (SWS, adj. β= -0.58 cm/min; p=0.025) and rapid eye movement (REM) sleep (adj. β= -0.62 cm/min; p=0.002) were both inversely related to waist circumference. Moreover, duration of REM sleep was inversely related to sagittal abdominal diameter (adj. β= -0.021 cm/min; p<0.0001). These associations were stronger in young women (age <50 years). Conclusion: An inverse relationship between short sleep duration and central obesity was found in women after adjusting for confounders. Loss of SWS and REM sleep may be contributing factors to the development of central obesity. By increasing the duration and quality of sleep, central obesity in women may be reduced.

sted, utgiver, år, opplag, sider
2010. Vol. 33, nr 5, s. 593-598
Emneord [en]
sleep, obesity, women, population-based, sleep duration, sleep stages, central obesity, women, population-based
HSV kategori
Forskningsprogram
Lungmedicin
Identifikatorer
URN: urn:nbn:se:uu:diva-99077ISI: 000277232200006OAI: oai:DiVA.org:uu-99077DiVA, id: diva2:202076
Tilgjengelig fra: 2009-03-06 Laget: 2009-03-06 Sist oppdatert: 2017-12-13
Inngår i avhandling
1. Sleep and Sleep-disordered Breathing in Women: Associations with Daytime Symptoms and Metabolism
Åpne denne publikasjonen i ny fane eller vindu >>Sleep and Sleep-disordered Breathing in Women: Associations with Daytime Symptoms and Metabolism
2009 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Obstructive sleep apnea (OSA) is characterized by snoring, apneas and excessive daytime sleepiness (EDS). Although commonly present in OSA, factors relating to daytime sleepiness are not fully elucidated. OSA is associated with obesity and with cardiovascular disease, type 2 diabetes mellitus and the metabolic syndrome.

In this population-based study 7,051 women answered a questionnaire on sleep and health. Psychological distress, insomnia and somatic disease were the factors most strongly related to both EDS and fatigue independent of other factors. Snoring was independently associated with both EDS and fatigue, but the associations were relatively weak.

In addition, 400 of the women underwent polysomnography and an oral glucose tolerance test. OSA was associated with changes in glucose metabolism independently of confounders such as central obesity. Moreover, low minimal saturation was independently associated with reduced insulin sensitivity.

In women sleeping <6-7 hours there was a substantial increase in waist circumference and short sleep duration remained associated with central obesity, even after adjusting for body mass index (BMI). The most pronounced negative influence of short sleep duration and also reduced duration of slow-wave sleep (SWS) or rapid eye movement (REM) sleep was seen in women <50 years.

All measures of OSA were related to the metabolic syndrome after adjustments. In addition, the relationship remained after adjusting for central or general obesity. Hypoxia was independently associated with hypertriglyceridemia, even after adjusting for BMI.

In conclusion, OSA may have significant impact on insulin sensitivity and metabolism in women, and the relationship could, to some extent, be mediated through hypoxia. Moreover, reduced sleep duration and loss of SWS and REM sleep may influence central obesity; a strong risk factor for OSA. Daytime sleepiness was most strongly related to psychological distress, insomnia and somatic disease although snoring was also a risk factor. This finding indicates that sleep apnea is only one factor contributing to daytime sleepiness in women.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2009. s. 73
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 438
Identifikatorer
urn:nbn:se:uu:diva-99080 (URN)978-91-554-7467-6 (ISBN)
Disputas
2009-04-24, Enghoff-salen, Akademiska sjukhuset, Ing 50, Uppsala, 13:15 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2009-04-03 Laget: 2009-03-06 Sist oppdatert: 2009-09-04bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

http://www.journalsleep.org/ViewAbstract.aspx?pid=27781

Søk i DiVA

Av forfatter/redaktør
Theorell-Haglöw, Jenny
Av organisasjonen
I samme tidsskrift
Sleep

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 473 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf