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Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. (Reumatologi)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi.
Vise andre og tillknytning
2008 (engelsk)Inngår i: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 141, nr 1, s. 69-72Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.

sted, utgiver, år, opplag, sider
2008. Vol. 141, nr 1, s. 69-72
Emneord [en]
human germinal-centre-associated protein, lymphoma, rheumatoid arthritis, diffuse large B-cell lymphoma, B-cells
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-102396DOI: 10.1111/j.1365-2141.2008.07011.xISI: 000253757400008PubMedID: 18324968OAI: oai:DiVA.org:uu-102396DiVA, id: diva2:216083
Tilgjengelig fra: 2009-05-06 Laget: 2009-05-06 Sist oppdatert: 2017-12-13bibliografisk kontrollert

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Baecklund, EvaBacklin, CarinEnblad, GunillaSundström, ChristerRosenquist, Richard

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