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Incomplete hippocampal inversion-is there a relation to epilepsy?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Raininko, R)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
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2009 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 19, no 10, p. 2544-2550Article in journal (Refereed) Published
Abstract [en]

Incomplete hippocampal inversion (IHI) has been described in patients with epilepsy or severe midline malformations but also in nonepileptic subjects without obvious developmental anomalies. We studied the frequency of IHI in different epilepsy syndromes to evaluate their relationship. Three hundred patients were drawn from the regional epilepsy register. Of these, 99 were excluded because of a disease or condition affecting the temporal lobes or incomplete data. Controls were 150 subjects without epilepsy or obvious intracranial developmental anomalies. The coronal MR images were analysed without knowledge of the clinical data. Among epilepsy patients, 30% had IHI (40 left-sided, 4 right-sided, 16 bilateral). Of controls, 18% had IHI (20 left-sided, 8 bilateral). The difference was statistically significant (P < 0.05). Of temporal lobe epilepsy (TLE) patients, 25% had IHI, which was not a significantly higher frequency than in controls (P = 0.34). There was no correlation between EEG and IHI laterality. A total of 44% of Rolandic epilepsy patients and 57% of cryptogenic generalised epilepsy patients had IHI. The IHI frequency was very high in some epileptic syndromes, but not significantly higher in TLE compared to controls. No causality between TLE and IHI could be found. IHI can be a sign of disturbed cerebral development affecting other parts of the brain, maybe leading to epilepsy.

Place, publisher, year, edition, pages
2009. Vol. 19, no 10, p. 2544-2550
Keywords [en]
Hippocampus, Developmental brain anomalies, MRI, Epilepsy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-105372DOI: 10.1007/s00330-009-1438-yISI: 000270268700029PubMedID: 19440714OAI: oai:DiVA.org:uu-105372DiVA, id: diva2:221156
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2022-01-28Bibliographically approved

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Bajic, DraganRaininko, Raili

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Bajic, DraganKumlien, EvaMattsson, PeterLundberg, StaffanRaininko, Raili
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