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Incomplete hippocampal inversion-is there a relation to epilepsy?
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi, Enheten för radiologi. (Raininko, R)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
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2009 (engelsk)Inngår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 19, nr 10, s. 2544-2550Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Incomplete hippocampal inversion (IHI) has been described in patients with epilepsy or severe midline malformations but also in nonepileptic subjects without obvious developmental anomalies. We studied the frequency of IHI in different epilepsy syndromes to evaluate their relationship. Three hundred patients were drawn from the regional epilepsy register. Of these, 99 were excluded because of a disease or condition affecting the temporal lobes or incomplete data. Controls were 150 subjects without epilepsy or obvious intracranial developmental anomalies. The coronal MR images were analysed without knowledge of the clinical data. Among epilepsy patients, 30% had IHI (40 left-sided, 4 right-sided, 16 bilateral). Of controls, 18% had IHI (20 left-sided, 8 bilateral). The difference was statistically significant (P < 0.05). Of temporal lobe epilepsy (TLE) patients, 25% had IHI, which was not a significantly higher frequency than in controls (P = 0.34). There was no correlation between EEG and IHI laterality. A total of 44% of Rolandic epilepsy patients and 57% of cryptogenic generalised epilepsy patients had IHI. The IHI frequency was very high in some epileptic syndromes, but not significantly higher in TLE compared to controls. No causality between TLE and IHI could be found. IHI can be a sign of disturbed cerebral development affecting other parts of the brain, maybe leading to epilepsy.

sted, utgiver, år, opplag, sider
2009. Vol. 19, nr 10, s. 2544-2550
Emneord [en]
Hippocampus, Developmental brain anomalies, MRI, Epilepsy
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Identifikatorer
URN: urn:nbn:se:uu:diva-105372DOI: 10.1007/s00330-009-1438-yISI: 000270268700029PubMedID: 19440714OAI: oai:DiVA.org:uu-105372DiVA, id: diva2:221156
Tilgjengelig fra: 2009-06-03 Laget: 2009-06-03 Sist oppdatert: 2017-12-13bibliografisk kontrollert

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