uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors
Visa övriga samt affilieringar
2008 (Engelska)Ingår i: Planta Medica, ISSN 0032-0943, E-ISSN 1439-0221, Vol. 74, nr 5, s. 491-496Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Naturally occurring benzodiazepines have been identified in regular food such as wheat and potato, but there is still no evidence that potato extracts can affect CNS responses in vivo. Here we found that undiluted potato juice and potato juice diluted with saline 1:2 administered 10 min intracisternally (i.c.) and 30 min per os before bicuculline exerted significant anticonvulsant activity in the bicuculline-induced seizure threshold test in mice. In vitro, potato juice from different harvests at dilution series from 10% to 0.000001%, diluted 100,000-fold, displaced 50% of gamma-aminobutyric acid (GABA) receptor ligand [H-3]GABA and diluted 40-fold displaced 50% of [H-3]flunitrazepam from binding sites in mice forebrain membranes. The low content of diazepam (0.04 +/- 0.01 mg/kg) determined by HPLC and mass spectrometry in the potato extracts could not sustain the anticonvulsant activity of potato juice in vivo; therefore we hypothesized that potato juice might contain GABA(A) receptor GABA-site active compounds. The findings of this study suggest that potato juice as well as potato taken as food may have the capacity of influencing brain GABA-ergic activity.

Ort, förlag, år, upplaga, sidor
2008. Vol. 74, nr 5, s. 491-496
Nyckelord [en]
Solarium tuberosum L., Solanaceae, potato, benzodiazepine, GABA receptors, radioligand receptor binding, bicuculline seizures
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-110197DOI: 10.1055/s-2008-1074495ISI: 000255869200002PubMedID: 18543146OAI: oai:DiVA.org:uu-110197DiVA, id: diva2:275534
Tillgänglig från: 2009-11-05 Skapad: 2009-11-05 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed
Av organisationen
Institutionen för neurovetenskap
I samma tidskrift
Planta Medica
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 421 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf