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Effect of inner ear blood flow changes on the endolymphatic sac
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
2008 (engelsk)Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 128, nr 11, s. 1187-95Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

CONCLUSIONS: That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure. OBJECTIVES: To elucidate the effect of changes in inner ear blood flow on the ES and to learn more about the volume and pressure regulatory function of the ES. MATERIALS AND METHODS: Epinephrine or sodium nitroprusside (SNP) was injected into the middle ear cavity of adult CBA/J mice. The ES were analyzed morphologically by light microscopy. RESULTS: Epinephrine reduced the luminal size of the ES leading to an accumulation of intraluminal homogeneous substance. Injection of SNP increased the size of the ES lumen, accompanied by a collapse of the lateral intercellular space (LIS) and dense perisaccular tissue. These changes were almost reversed 4 h after injection.

sted, utgiver, år, opplag, sider
2008. Vol. 128, nr 11, s. 1187-95
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URN: urn:nbn:se:uu:diva-113594DOI: 10.1080/00016480801910387ISI: 000260032900004PubMedID: 18607967OAI: oai:DiVA.org:uu-113594DiVA, id: diva2:291327
Tilgjengelig fra: 2010-02-01 Laget: 2010-02-01 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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