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Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men
Vise andre og tillknytning
2009 (engelsk)Inngår i: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 94, nr 3, s. 1033-1041Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Context:

The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids.

Objective:

The aim of the study was to identify genetic variations in sex steroid-related genes that are associated with serum levels of estradiol (E2) and/or testosterone in men.

Design:

Genotyping of 604 single nucleotide polymorphisms in 50 sex steroid-related candidate genes was performed in the Gothenburg Osteoporosis and Obesity Determinants (GOOD) study (n = 1041 men; age, 18.9 ± 0.6 yr). Replications of significant associations were performed in the Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2568 men; age, 75.5 ± 3.2 yr) and in the MrOS US study (n = 1922 men; age, 73.5 ± 5.8 yr). Serum E2, testosterone, and estrone (E1) levels were analyzed using gas chromatography/mass spectrometry.

Results:

The screening in the GOOD cohort identified the single nucleotide polymorphism rs2470152 in intron 1 of the CYP19 gene, which codes for aromatase, responsible for the final step of the biosynthesis of E2 and E1, to be most significantly associated with serum E2 levels (P = 2 × 10−6). This association was confirmed both in the MrOS Sweden study (P = 9 × 10−7) and in the MrOS US study (P = 1 × 10−4). When analyzed in all subjects (n = 5531), rs2470152 was clearly associated with both E2 (P = 2 × 10−14) and E1 (P = 8 × 10−19) levels. In addition, this polymorphism was modestly associated with lumbar spine BMD (P < 0.01) and prevalent self-reported fractures (P < 0.05).

Conclusions:

rs2470152 of the CYP19 gene is clearly associated with serum E2 and E1 levels in men.

sted, utgiver, år, opplag, sider
2009. Vol. 94, nr 3, s. 1033-1041
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-125046DOI: 10.1210/jc.2008-1283ISI: 000264020700048PubMedID: 19116238OAI: oai:DiVA.org:uu-125046DiVA, id: diva2:318351
Tilgjengelig fra: 2010-05-07 Laget: 2010-05-07 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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