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Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi, Enheten för biomedicinsk strålningsvetenskap.ORCID-id: 0000-0001-6120-2683
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2009 (engelsk)Inngår i: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 19, nr 14, s. 3912-3914Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Affibody molecules represent a novel class of affinity proteins with a high potential as tracers for radio-nuclide molecular imaging. In this comparative structure-property study, a series of Affibody molecules with the Tc-99m-chelators maGGG, maSSS, or maESE attached to the e-amine of the internally positioned K49 was prepared by peptide synthesis, for comparison to molecules with similar chelators positioned at the N-terminus. The conjugates were labeled with Tc-99m and evaluated in vitro and in vivo. It was found that both composition and position of the chelating moiety influence the label stability, biodistribution and targeting properties of HER2-binding Affibody molecules. (C) 2009 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
2009. Vol. 19, nr 14, s. 3912-3914
Emneord [en]
Affibody molecule, Tc chelator, Molecular imaging, Peptide synthesis
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Identifikatorer
URN: urn:nbn:se:uu:diva-128387DOI: 10.1016/j.bmcl.2009.03.083ISI: 000267762600051OAI: oai:DiVA.org:uu-128387DiVA, id: diva2:331513
Tilgjengelig fra: 2010-07-23 Laget: 2010-07-20 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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