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Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Polymer international, ISSN 0959-8103, E-ISSN 1097-0126, Vol. 59, nr 11, s. 1558-1562Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Melt electrospinning is one aspect of electrospinning with relatively little published literature, although the technique avoids solvent accumulation and/or toxicity which is favoured in certain applications In the study reported, we melt-electrospun blends of poly(epsilon-caprolactone) (PCL) and an amphiphilic diblock copolymer consisting of poly(ethylene glycol) and PCL segments (PEG-block PCL) A custom-made electrospinning apparatus was built and various combinations of instrument parameters such as voltage and polymer feeding rate were investigated Pure PEG-block-PCL copolymer melt electrospinning did not result in consistent and uniform fibres due to the low molecular weight, while blends of PCL and PEG-block-PCL, for some parameter combinations and certain weight ratios of the two components, were able to produce continuous fibres significantly thinner (average diameter of ca 2 mu m) compared to pure PCL The PCL fibres obtained had average diameters ranging from 6 to 33 mu m and meshes were uniform for the lowest voltage employed while mesh uniformity decreased when the voltage was increased This approach shows that PCL and blends of PEG block-PCL and PCL can be readily processed by melt electrospinning to obtain fibrous meshes with varied average diameters and morphologies that are of interest for tissue engineering purposes.

sted, utgiver, år, opplag, sider
2010. Vol. 59, nr 11, s. 1558-1562
Emneord [en]
electrospinning, amphiphilic polymer, block copolymer, tissue engineering
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-135310DOI: 10.1002/pi.2954ISI: 000284023900013OAI: oai:DiVA.org:uu-135310DiVA, id: diva2:375693
Tilgjengelig fra: 2010-12-08 Laget: 2010-12-06 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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