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Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
2010 (engelsk)Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, nr 12, s. S128-S134Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

The identification of disease-causing mutations in Alzheimer's disease has contributed greatly to the understanding of the pathogenesis of this disease. The amyloid-beta (A beta) peptide has come into focus and is believed to be central to the pathogenesis of Alzheimer's disease. With only symptomatic treatment available, efforts to develop new therapeutics aimed at lowering the amount of A beta peptides in the affected brain have intensified. In particular, immunotherapy against A beta peptides has attracted considerable interest, as it offers the possibility to generate highly specific molecules targeting highly specific moieties. Due to intense research efforts and massive investments at universities and in the pharmaceutical industry, the outlook for patients and their relatives has never been brighter.

sted, utgiver, år, opplag, sider
2010. Vol. 68, nr 12, s. S128-S134
Emneord [en]
Alzheimer's disease, amyloid-beta protein, immunotherapy, protofibrils, transgenic mice
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-140029DOI: 10.1111/j.1753-4887.2010.00347.xISI: 000284587300010PubMedID: 21091946OAI: oai:DiVA.org:uu-140029DiVA, id: diva2:382857
Tilgjengelig fra: 2011-01-03 Laget: 2011-01-03 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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