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Basic aspects of exhaled nitric oxide
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik. (Allmänpediatrisk forskning/ Nordvall)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
2010 (engelsk)Inngår i: European Respiratory Monograph, ISSN 1025-448X, E-ISSN 2075-6674, Vol. 49, s. 1-31Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Nitric oxide (NO) in orally exhaled air mainly originates fromthe respiratory epithelium. NO is produced by inducible NOsynthase (iNOS), which is regulated by signal transducer andactivator of transcription (STAT)-1 under the influence ofhomeostatic interferon-c. In patients with asthma, iNOSexpression is upregulated by interleukin (IL)-4 and IL-13 viathe activation of STAT-6 in the bronchial epithelium. Thus,exhaled NO primarily signals local T-helper cell type 2-driveninflammation in the bronchial mucosa. With these character-istics, exhaled NO will be a suitable marker for predicting theresponse to inhaled corticosteroids, and to monitor the anti-inflammatory effect.The methodology for measuring exhaled NO has beenstandardised based on international consensus. The determi-nants of exhaled NO levels are fairly well characterised, withthe most important being cigarette smoking, nitrate intake, airpollution, allergen sensitisation and exposure, along withheight, sex and age. A future development may be the estima-tion of peripheral airway inflammation by measuring exhaledNO at multiple exhalation flow rates.

sted, utgiver, år, opplag, sider
2010. Vol. 49, s. 1-31
Emneord [en]
Asthma, breath test, eosinophil, epithelium, nitric oxide, signal transducer and activator of transcription-6
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Identifikatorer
URN: urn:nbn:se:uu:diva-140836DOI: 10.1183/1025448x.00028509OAI: oai:DiVA.org:uu-140836DiVA, id: diva2:384488
Tilgjengelig fra: 2011-01-10 Laget: 2011-01-10 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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