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Monoamine oxidases: activities, genotypes and the shaping of behaviour
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
2007 (engelsk)Inngår i: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 114, nr 6, s. 817-822Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The importance of an interaction between environment and biological factors for the expression for a particular behaviour is illustrated by results from a series of adolescents in which effects of platelet MAO activity and psychosocial environment on criminality was investigated. In a favourable environment platelet MAO-B activity was not associated with criminality, while a very strong association was found in adolescents from a bad psychosocial environment. Essentially similar findings were obtained when a MAO-A promoter polymorphism was analysed instead of platelet MAO-B activity. In boys, presence of the low functioning allele seemed to be protective against criminal activity in combination with a good environment, while it predisposed for criminality in a bad psycho-social environment. In girls, instead, homozygosity for the high activity MAO-A allele interacted with environment to predict criminality. Possible mechanisms underlying the role of monoamine oxidases for behaviour are discussed.

sted, utgiver, år, opplag, sider
2007. Vol. 114, nr 6, s. 817-822
Emneord [en]
Monoamine oxidase, genotype, personality, behaviour, platelet
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-11434DOI: 10.1007/s00702-007-0694-8ISI: 000246735100025PubMedID: 17426915OAI: oai:DiVA.org:uu-11434DiVA, id: diva2:39203
Tilgjengelig fra: 2008-03-25 Laget: 2008-03-25 Sist oppdatert: 2018-05-31bibliografisk kontrollert

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