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Laparoscopically assisted vs open colectomy for colon cancer: a meta-analysis
Vise andre og tillknytning
2007 (engelsk)Inngår i: Archives of surgery (Chicago. 1960), ISSN 0004-0010, E-ISSN 1538-3644, Vol. 142, nr 3, s. 298-303Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To perform a meta-analysis of trials randomizing patients with colon cancer to laparoscopically assisted or open colectomy to enhance the power in determining whether laparoscopic colectomy for cancer is oncologically safe. DATA SOURCES: The databases of the Barcelona, Clinical Outcomes of Surgical Therapy (COST), Colon Cancer Laparoscopic or Open Resection (COLOR), and Conventional vs Laparoscopic-Assisted Surgery in Patients With Colorectal Cancer (CLASICC) trials were the data sources for the study. STUDY SELECTION: Patients who had at least 3 years of complete follow-up data were selected. DATA EXTRACTION: Patients who had undergone curative surgery before March 1, 2000, were studied. Three-year disease-free survival and overall survival were the primary outcomes of this analysis. DATA SYNTHESIS: Of 1765 patients, 229 were excluded, leaving 796 patients in the laparoscopically assisted arm and 740 patients in the open arm for analysis. Three-year disease-free survival rates in the laparoscopically assisted and open arms were 75.8% and 75.3%, respectively (95% confidence interval [CI] of the difference, -5% to 4%). The associated common hazard ratio (laparoscopically assisted vs open surgery with adjustment for sex, age, and stage) was 0.99 (95% CI, 0.80-1.22; P = .92). The 3-year overall survival rate after laparoscopic surgery was 82.2% and after open surgery was 83.5% (95% CI of the difference, -3% to 5%). The associated hazard ratio was 1.07 (95% CI, 0.83-1.37; P = .61). Disease-free and overall survival rates for stages I, II, and III evaluated separately did not differ between the 2 treatments. CONCLUSION: Laparoscopically assisted colectomy for cancer is oncologically safe.

sted, utgiver, år, opplag, sider
2007. Vol. 142, nr 3, s. 298-303
Emneord [en]
Colectomy/*methods, Colonic Neoplasms/*surgery, Follow-Up Studies, Humans, Laparoscopy, Randomized Controlled Trials, Treatment Outcome
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-11842ISI: 000244717700022PubMedID: 17372057OAI: oai:DiVA.org:uu-11842DiVA, id: diva2:39611
Merknad
Group Author(s): Transatlantic Laparoscopically assTilgjengelig fra: 2007-10-26 Laget: 2007-10-26 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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