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Blood lipids in 75,048 type 2 diabetic patients: a population-based survey from the Swedish National diabetes register
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
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2011 (Engelska)Ingår i: European Journal of Cardiovascular Prevention & Rehabilitation, ISSN 1741-8267, E-ISSN 1741-8275, Vol. 18, nr 1, s. 97-105Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood lipid profiles and clinical characteristics in 75,048 type 2 diabetic patients (57% men) were studied. Results: Pronounced hypertriglyceridemia (triglycerides >4.0mmol/l) was seen in 3.4% of the patients. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and non-HDL-C were generally higher, and LDL-C/HDL-C and Non-HDL-C/HDL-C ratios were lower in women. Mean TC, LDL-C as well as HDL-C values were lower in patients treated with lipid-lowering agents, whereas triglycerides was higher than in the untreated patients. In patients not treated with lipid-lowering agents all blood lipids increased in women and decreased in men (except HDL-C) at higher ages. Patients with LDL-C/HDL-C ratio >= 3 were slightly younger, less frequently used lipid-lowering drugs and had not so often a history of coronary heart disease or stroke. Conclusion: The distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes.

Ort, förlag, år, upplaga, sidor
2011. Vol. 18, nr 1, s. 97-105
Nyckelord [en]
Blood lipids, cholesterol, epidemiology, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, type 2 diabetes
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-149036DOI: 10.1097/HJR.0b013e32833ba61eISI: 000287780400011PubMedID: 21354969OAI: oai:DiVA.org:uu-149036DiVA, id: diva2:403896
Tillgänglig från: 2011-03-15 Skapad: 2011-03-15 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Zethelius, BjörnCederholm, Jan

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