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Comparison of [177Lu-DOTA0,Tyr3]-Octreotate and [177Lu-DOTA0,Tyr3]-Octreotide for Receptor-Mediated Radiation Therapy of the Xenografted Human Midgut Carcinoid Tumor GOT1
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2008 (Engelska)Ingår i: Cancer Biotherapy and Radiopharmaceuticals, ISSN 1084-9785, E-ISSN 1557-8852, Vol. 23, nr 1, s. 114-120Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The aim of this study was to compare the tumor uptake versus time and the tumor response in nude mice transplanted with a human midgut carcinoid (GOT1), when treated with either [177Lu-DOTA0,Tyr3]-octreotide or [177Lu-DOTA0,Tyr3]-octreotate and to evaluate if plasma chromogranin A (P-CgA) was a reliable marker of tumor response. The tumor uptake and retention of activity of a single intravenous (i.v.) dose (15 MBq) of [177Lu-DOTA0,Tyr3]-octreotate or [177Lu-DOTA0,Tyr3]-octreotide were compared in nude mice xenografted with GOT1. The activity concentration 24 hours after injection was significantly higher in animals given [177Lu-DOTA0,Tyr3]-octreotate versus [177Lu-DOTA0,Tyr3]-octreotide (16% ± 1.4% of injected activity per gram [%IA/g] vs. 8.1% ± 2.1% IA/g, mean ± standard error of the mean) (p = 0.00061). The mean absorbed dose was higher in animals given [177Lu-DOTA0,Tyr3]-octreotate (46 ± 4.3 vs. 17 ± 3.4 Gy). The reduction of tumor volume was accordingly more prominent in animals given [177Lu-DOTA0,Tyr3]-octreotate than in animals given [177Lu-DOTA0,Tyr3]-octreotide (p = 0.003). The mean tumor volume for animals given [177Lu-DOTA0,Tyr3]-octreotate was reduced to 3% of its initial value. P-CgA values were strongly correlated with tumor volume. Octreotate seems to be a more suitable somatostatin analog than octreotide for receptor-mediated radiation therapy. P-CgA is a simple, accurate method for the estimation of tumor response in this animal model.

Ort, förlag, år, upplaga, sidor
2008. Vol. 23, nr 1, s. 114-120
Nyckelord [en]
octreotate, octreotide, somatostatin receptor, carcinoid, chromogranin A
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Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-152597DOI: 10.1089/cbr.2007.0421ISI: 000254025100012OAI: oai:DiVA.org:uu-152597DiVA, id: diva2:413531
Tillgänglig från: 2011-04-28 Skapad: 2011-04-28 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Stridsberg, Mats

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