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Antihyperglycaemic treatment of type 2 diabetes: results from a national diabetes register
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och klinisk epidemiologi.
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2007 (Engelska)Ingår i: Diabetes & Metabolism, ISSN 1262-3636, E-ISSN 1878-1780, Vol. 33, nr 4, s. 269-276Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim

To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes.

Methods

We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study from 1996 to 2004. HbA1c, risk factors and treatments were determined locally in primary care as well as hospital outpatient clinics.

Results

Insulin was frequently used in DM2 patients with long duration of diabetes, although the mean HbA1c increased and only a few in this group reached HbA1c < 7.0%. Patients showing long-term improvement in HbA1c (> 1%) from 1996 to 2004 were more often treated with insulin than with oral hypoglycaemic agents (OHA). During this period, the HbA1c levels leading to additional treatment decreased. A low BMI, decreasing BMI and not smoking were predictors of good long-term metabolic control. Hypertension and hyperlipidaemia were frequent in both newly diagnosed DM2 patients and in patients with a long duration of diabetes.

Conclusions

Insulin treatment was frequently used, particularly in patients with a long duration of DM2. The glycaemic control, which usually deteriorates over time, did not reach the recommended goal, despite the fact that complementary treatment was added at lower HbA1c levels in 2003 than in 1996. High frequencies of hypertension, hyperlipidaemia and high 10-year risks of coronary heart disease necessitate intensified risk factor control in the future.

Ort, förlag, år, upplaga, sidor
2007. Vol. 33, nr 4, s. 269-276
Nyckelord [en]
Diabetes mellitus, Epidemiology, Insulin, Hypoglycaemic agents, Hypertension, National register
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-14871DOI: 10.1016/j.diabet.2007.02.003ISI: 000250111600005PubMedID: 17499541OAI: oai:DiVA.org:uu-14871DiVA, id: diva2:42642
Tillgänglig från: 2008-01-31 Skapad: 2008-01-31 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Förlagets fulltextPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17499541&dopt=Citation

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Cederholm, Jan

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