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Agreement between physicians' and patients' ratings on the Montgomery-Asberg Depression Rating Scale
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
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2011 (Engelska)Ingår i: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 135, nr 1-3, s. 148-153Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Self-rating scales developed for monitoring depression severity are potentially informative and cost effective tools. There is an increasing tendency to use the Montgomery-Asberg Depression Rating Scale (MADRS) and the self-rating version (MADRS-S) interchangeably.

Methods: 400 patients with major depressive disorder were included. Concordance between patient and physician ratings was measured by means of repeated MADRS and MADRS-S ratings during a six-month drug trial and one-year follow-up.

Results: Overall scores from patients and physicians show the same trends and both are sensitive to improvements. Our results, however, show only moderate to good agreement between patient and physician ratings. Intraclass coefficients ranged from 0.47 to 0.75 with highest agreement at week 8.

Limitations: Generalizability is restricted to outpatients in general practice with moderate to severe depression. MADRS-S and MADRS scale definitions are similar but not identical concerning language and are scaled differently, 0-6 vs. 0-3, respectively, which may have influenced the results. The exclusion criteria restricted the range of values for the item Suicidal thoughts/Zest for life, which may have reduced the correlations.

Conclusions: MADRS-S is a suitable tool for following patients' symptoms on a regular basis over time and may also be used to compensate for bias in physicians' ratings in drug trials.

Ort, förlag, år, upplaga, sidor
2011. Vol. 135, nr 1-3, s. 148-153
Nyckelord [en]
Montgomery-Asberg Depression Rating Scale, Self-rating scales, Depression
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-167930DOI: 10.1016/j.jad.2011.07.005ISI: 000297908200021OAI: oai:DiVA.org:uu-167930DiVA, id: diva2:489062
Tillgänglig från: 2012-02-02 Skapad: 2012-02-02 Senast uppdaterad: 2017-12-08Bibliografiskt granskad

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Cunningham, Janet L.Wernroth, Lisavon Knorring, LarsBerglund, LarsEkselius, Lisa

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Cunningham, Janet L.Wernroth, Lisavon Knorring, LarsBerglund, LarsEkselius, Lisa
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Psykiatri, Akademiska sjukhusetUppsala kliniska forskningscentrum (UCR)
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Journal of Affective Disorders
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