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Joint analysis of demography and selection in population genetics: where do we stand and where could we go?
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
Vise andre og tillknytning
2012 (engelsk)Inngår i: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 21, nr 1, s. 28-44Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Teasing apart the effects of selection and demography on genetic polymorphism remains one of the major challenges in the analysis of population genomic data. The traditional approach has been to assume that demography would leave a genome-wide signature, whereas the effect of selection would be local. In the light of recent genomic surveys of sequence polymorphism, several authors have argued that this approach is questionable based on the evidence of the pervasive role of positive selection and that new approaches are needed. In the first part of this review, we give a few empirical and theoretical examples illustrating the difficulty in teasing apart the effects of selection and demography on genomic polymorphism patterns. In the second part, we review recent efforts to detect recent positive selection. Most available methods still rely on an a priori classification of sites in the genome but there are many promising new approaches. These new methods make use of the latest developments in statistics, explore aspects of the data that had been neglected hitherto or take advantage of the emerging population genomic data. A current and promising approach is based on first estimating demographic and genetic parameters, using, e.g., a likelihood or approximate Bayesian computation framework, focusing on extreme outlier regions, and then using an independent method to confirm these. Finally, especially for species where evidence of natural selection has been limited, more experimental and versatile approaches that contrast populations under varied environmental constraints might be more successful compared with species-wide genome scans in search of specific signatures.

sted, utgiver, år, opplag, sider
2012. Vol. 21, nr 1, s. 28-44
Emneord [en]
contemporary evolution, ecological genetics, population geneticsutheoretical, population geneticsuempirical
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-169316DOI: 10.1111/j.1365-294X.2011.05308.xISI: 000298582700004OAI: oai:DiVA.org:uu-169316DiVA, id: diva2:506230
Tilgjengelig fra: 2012-02-28 Laget: 2012-02-28 Sist oppdatert: 2017-12-07bibliografisk kontrollert
Inngår i avhandling
1. Inferring Evolutionary Processes of Humans
Åpne denne publikasjonen i ny fane eller vindu >>Inferring Evolutionary Processes of Humans
2012 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

More and more human genomic data has become available in recent years by the improvement of DNA sequencing technologies. These data provide abundant genetic variation information which is an important resource to help us to understand the evolutionary history of humans. In this thesis I evaluated the performance of the Approximate Bayesian Computation (ABC) approach for inferring demographic parameters for large-scale population genomic data. According to simulation results, I can conclude that the ABC approach will continue to be a useful tool for analysing realistic genome-wide population-genetic data in the post-genomic era. Secondly, I implemented the ABC approach to estimate the pre-historic events connected with the “Bantu-expansion”, the spread of peoples from West Africa. The analysis based on genetic data with a large number of loci support a rapid population growth in west Africans, which lead to their concomitant spread to southern and eastern Africa. Contrary to hypotheses based on language studies, I found that Bantu-speakers in south Africa likely migrated directly from west Africa, and not from east Africa. Thirdly, I evaluated Thomson's estimator of the time to most recent common ancestor (TMRCA). It is robust to different recombination rates and the least-biased compared to other commonly used approaches. I used the Thomson estimator to infer the genome-wide distribution of TMRCA for complete human genome sequence data in various populations from across the world and compare the result to simulated data. Finally, I investigated and analysed the effects of selection and demography on genetic polymorphism patterns. In particular, we could detect a clear signal in the distribution of TMRCA caused by selection for a constant-size population. However, if the population was growing, the signal of selection will be difficult to detect under some circumstances. I also discussed and gave a few suggestions that might lead to a more realistic path of successful identification of genes targeted by selection in large-scale genomic data.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2012. s. 58
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 997
Emneord
Approximate Bayesian Computation, TMRCA, demography, human evolution, Bantu-Expansion, Out-of-Africa
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-183517 (URN)978-91-554-8538-2 (ISBN)
Disputas
2012-12-17, Lindhalsalen, Norbyvägen 18A, Uppsala, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2012-11-26 Laget: 2012-10-28 Sist oppdatert: 2013-07-22

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