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Prediction of nonrecovery in Bell's palsy using sunnybrook grading
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
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2012 (Engelska)Ingår i: The Laryngoscope, ISSN 0023-852X, E-ISSN 1531-4995, Vol. 122, nr 4, s. 901-906Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives/Hypothesis: To develop a clinical prognostic model to identify Bell's palsy patients with risk for nonrecovery at 12 months.

Study Design: Data from a prospective, randomized, double-blind, placebo-controlled, multicenter study.

Methods: There were 829 patients with Bell's palsy randomized in a factorial fashion to treatment with prednisolone or no prednisolone. Facial function was assessed with the Sunnybrook grading scale. Univariate and multivariate logistic regression analyses at different time points were used to identify factors predicting nonrecovery, defined as Sunnybrook < 70 at 12 months. Variables studied were age, gender, time to inclusion, prednisolone treatment, side of palsy, pain at inclusion, and Sunnybrook scores. Factors of predictable significance were used to construct prognostic models at baseline, days 11 to 17, and at 1 month. Receiver operating characteristics curves were created to test the predictive capacity of the models.

Results: At baseline, treatment with prednisolone or no prednisolone (P = .0005), age (P = .04) and the Sunnybrook score (P = .0002) were significant factors for predicting nonrecovery. The receiver operating characteristics area under the curve at baseline for these three variables was 0.74 (sensitivity 0.83, specificity 0.57). At days 11 to 17 and at 1 month, the Sunnybrook score was the only significant predictive variable. The respective areas under the curves for the Sunnybrook score at these time points were 0.83 (sensitivity 0.81, specificity 0.75) and 0.94 (sensitivity 0.91, specificity 0.85).

Conclusions: Sunnybrook grading at 1 month most accurately predicts nonrecovery at 12 months in Bell's palsy.

Ort, förlag, år, upplaga, sidor
2012. Vol. 122, nr 4, s. 901-906
Nyckelord [en]
Facial palsy, facial paralysis, facial nerve, prognosis, multivariate analysis, receiver operating characteristics, area under the curve, Level of Evidence: 1b
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-173334DOI: 10.1002/lary.23210ISI: 000301714800039OAI: oai:DiVA.org:uu-173334DiVA, id: diva2:517623
Tillgänglig från: 2012-04-24 Skapad: 2012-04-23 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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Bylund, NinaJonsson, LarsEngström, MatsHadziosmanovic, Nermin

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