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Clearance of iron oxide particles in rat liver: effect of hydrated particle size and coating material on liver metabolism
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi, Enheten för radiologi. (Ahlstrom)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi, Enheten för radiologi. (Ahlstrom)
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2006 (Engelska)Ingår i: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 41, nr 7, s. 560-571Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: We sought to evaluate the effect of the particle size and coating material of various iron oxide preparations on the rate of rat liver clearance. MATERIALS AND METHODS: The following iron oxide formulations were used in this study: dextran-coated ferumoxide (size = 97 nm) and ferumoxtran-10 (size = 21 nm), carboxydextran-coated SHU555A (size = 69 nm) and fractionated SHU555A (size = 12 nm), and oxidized-starch coated materials either unformulated NC100150 (size = 15 nm) or formulated NC100150 injection (size = 12 nm). All formulations were administered to 165 rats at 2 dose levels. Quantitative liver R2* values were obtained during a 63-day time period. The concentration of iron oxide particles in the liver was determined by relaxometry, and these values were used to calculate the particle half-lives in the liver. RESULTS: After the administration of a high dose of iron oxide, the half-life of iron oxide particles in rat liver was 8 days for dextran-coated materials, 10 days for carboxydextran materials, 14 days for unformulated oxidized-starch, and 29 days for formulated oxidized-starch. CONCLUSIONS: The results of the study indicate that materials with similar coating but different sizes exhibited similar rates of liver clearance. It was, therefore, concluded that the coating material significantly influences the rate of iron oxide clearance in rat liver.

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2006. Vol. 41, nr 7, s. 560-571
Nyckelord [en]
Animals, Contrast Media/*pharmacokinetics, Iron/*pharmacokinetics, Liver/*metabolism, Magnetic Resonance Imaging, Male, Oxides/*pharmacokinetics, Particle Size, Rats, Rats; Sprague-Dawley, Surface Properties
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-25033DOI: 10.1097/01.rli.0000221321.90261.09PubMedID: 16772849OAI: oai:DiVA.org:uu-25033DiVA, id: diva2:52807
Tillgänglig från: 2007-02-09 Skapad: 2007-02-09 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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Johansson, Lars O.

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