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Association between physical activity and brain health in older adults
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 0000-0002-8911-4068
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2013 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 34, no 1, p. 83-90Article in journal (Refereed) Published
Abstract [en]

In the present cross-sectional study, we examined physical activity (PA) and its possible association with cognitive skills and brain structure in 331 cognitively healthy elderly. Based on the number of self-reported light and hard activities for at least 30 minutes per week, participants were assigned to 4 groups representing different levels of PA. The cognitive skills were assessed by the Mini Mental State Examination score, a verbal fluency task, and the Trail-making test as a measure of visuospatial orientation ability. Participants also underwent a magnetic resonance imaging of the brain. Multiple regression analysis revealed that greater PA was associated with a shorter time to complete the Trail-making test, and higher levels of verbal fluency. Further, the level of self-reported PA was positively correlated with brain volume, white matter, as well as a parietal lobe gray matter volume, situated bilaterally at the precuneus. These present cross-sectional results indicate that PA is a lifestyle factor that is linked to brain structure and function in late life.

Place, publisher, year, edition, pages
2013. Vol. 34, no 1, p. 83-90
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-181182DOI: 10.1016/j.neurobiolaging.2012.04.013ISI: 000311026700007PubMedID: 22592017OAI: oai:DiVA.org:uu-181182DiVA, id: diva2:553337
Available from: 2012-09-18 Created: 2012-09-18 Last updated: 2023-09-05Bibliographically approved

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Benedict, ChristianBrooks, Samantha JKullberg, JoelNordenskjöld, RichardLe Grevès, MadeleineKilander, LenaLarsson, Elna-MarieJohansson, LarsAhlström, HåkanLind, LarsSchiöth, Helgi B

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Benedict, ChristianBrooks, Samantha JKullberg, JoelNordenskjöld, RichardLe Grevès, MadeleineKilander, LenaLarsson, Elna-MarieJohansson, LarsAhlström, HåkanLind, LarsSchiöth, Helgi B
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