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Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för radiologi, onkologi och strålningsvetenskap, Enheten för nuklearmedicin och PET.
P.A.I.N. Group, Department of Anesthesia, Children's Hospital, Boston, MA, USA.
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2014 (Engelska)Ingår i: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 17, nr 8, s. 1149-1157Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
2014. Vol. 17, nr 8, s. 1149-1157
Nationell ämneskategori
Neurovetenskaper
Forskningsämne
Neurovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-181547DOI: 10.1017/S1461145714000352ISI: 000338098500004OAI: oai:DiVA.org:uu-181547DiVA, id: diva2:556654
Anmärkning

Correction in: International Journal of Neuropsychopharmacology, vol. 17, issue 8, page 1353.

Tillgänglig från: 2012-09-25 Skapad: 2012-09-25 Senast uppdaterad: 2018-01-12Bibliografiskt granskad
Ingår i avhandling
1. Mind really does matter: The Neurobiology of Placebo-induced Anxiety Relief in Social Anxiety Disorder
Öppna denna publikation i ny flik eller fönster >>Mind really does matter: The Neurobiology of Placebo-induced Anxiety Relief in Social Anxiety Disorder
2012 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The placebo effect, a beneficial effect attributable to a treatment containing no specific properties for the condition being treated, has been demonstrated in a variety of medical conditions. This thesis includes four studies aimed at increasing our knowledge on the neurobiology of placebo. Study I, a review of the placebo neuroimaging literature, suggested that the anterior cingulate cortex (ACC) may be a common site of action for placebo responses. However, because placebo neuroimaging studies in clinical disorders are largely lacking, the clinical relevance of this needs further clarification. The subsequent three empirical studies were thus designed from a clinical perspective. Using positron emission tomography (PET) these studies investigated the underlying neurobiology of sustained placebo responses in patients with social anxiety disorder (SAD), a disabling psychiatric condition that nonetheless may be mitigated by placebo interventions. Study II demonstrated that serotonergic gene polymorphisms affect anxiety-induced neural activity and the resultant placebo phenotype. In particular, anxiety reduction resulting from placebo treatment was tied to the attenuating effects of the TPH2 G-703T polymorphism on amygdala activity. Study III further compared the neural response profile of placebo with selective serotonin reuptake inhibitors (SSRIs), i.e the first-line pharmacological treatment for SAD. A similar anxiety reduction was noted in responders of both treatments. PET-data further revealed that placebo and SSRI responders had similar decreases of the neural response in amygdala subregions including the left basomedial/basolateral (BM/BLA) and the right ventrolateral (VLA) sections. To clarify whether successful placebo and SSRI treatments operate via similar or distinct neuromodulatory pathways, study IV focused on the connectivity patterns between the amygdala and prefrontal cortex that may be crucial for normal emotion regulation. In responders of both treatment modalities, the left amygdala (BM/BLA) exhibited negative coupling with the dorsolateral prefrontal cortex and the rostral ACC as well as a shared positive coupling with the dorsal ACC. This may represent shared treatment mechanisms involving improved emotion regulation and decreased rumination. This thesis constitutes a first step towards better understanding of the neurobiology of placebo in the treatment of anxiety, including the neural mechanisms that unite and segregate placebo and SSRI treatment.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2012. s. 92
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences, ISSN 1652-9030 ; 82
Nyckelord
Placebo effect, anxiolysis, SAD, PET, TPH2 G-703T polymorphism, SSRIs, amygdala subregions, prefrontal cortex.
Nationell ämneskategori
Humaniora
Forskningsämne
Psykologi
Identifikatorer
urn:nbn:se:uu:diva-181548 (URN)978-91-554-8478-1 (ISBN)
Disputation
2012-11-09, Auditorium Minus, Gustavianum, Akademigatan 3, Uppsala, 13:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2012-10-19 Skapad: 2012-09-25 Senast uppdaterad: 2013-01-23Bibliografiskt granskad

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Faria, VandaAppel, LieuweFredrikson, MatsFurmark, Tomas

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