The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancerVise andre og tillknytning
2013 (engelsk)Inngår i: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 333, nr 2, s. 222-228Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma–infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.
sted, utgiver, år, opplag, sider
2013. Vol. 333, nr 2, s. 222-228
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Identifikatorer
URN: urn:nbn:se:uu:diva-181908DOI: 10.1016/j.canlet.2013.01.036ISI: 000318838700011OAI: oai:DiVA.org:uu-181908DiVA, id: diva2:558058
2012-10-012012-10-012022-01-28bibliografisk kontrollert
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