uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review
Visa övriga samt affilieringar
2012 (Engelska)Ingår i: Intensive Care Medicine, ISSN 0342-4642, E-ISSN 1432-1238, Vol. 38, nr 9, s. 1418-1428Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

PURPOSE:

Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system. We reviewed the usefulness of systemic levels of suPAR in the care of critically ill patients with sepsis, SIRS, and bacteremia, focusing on its diagnostic and prognostic value.

METHODS:

A PubMed search on suPAR was conducted, including manual cross-referencing. The list of papers was narrowed to original studies of critically ill patients. Ten papers on original studies of critically ill patients were identified that report on suPAR in sepsis, SIRS, or bacteremia.

RESULTS:

Systematic levels of suPAR have little diagnostic value in critically ill patients with sepsis, SIRS, or bacteremia. Systemic levels of suPAR, however, have superior prognostic power over other commonly used biological markers in these patients. Mortality prediction by other biological markers or severity-of-disease classification system scores improves when combining them with suPAR. Systemic levels of suPAR correlate positively with markers of organ dysfunction and severity-of-disease classification system scores. Finally, systemic levels of suPAR remain elevated for prolonged periods after admission and only tend to decline after several weeks. Notably, the type of assay used to measure suPAR as well as the age of the patients and underlying disease affect systemic levels of suPAR.

CONCLUSIONS:

The diagnostic value of suPAR is low in patients with sepsis. Systemic levels of suPAR have prognostic value, and may add to prognostication of patients with sepsis or SIRS complementing severity-of-disease classification systems and other biological markers.

Ort, förlag, år, upplaga, sidor
2012. Vol. 38, nr 9, s. 1418-1428
Nationell ämneskategori
Anestesi och intensivvård
Identifikatorer
URN: urn:nbn:se:uu:diva-192641DOI: 10.1007/s00134-012-2613-1ISI: 000307764300002PubMedID: 22706919OAI: oai:DiVA.org:uu-192641DiVA, id: diva2:600304
Tillgänglig från: 2013-01-24 Skapad: 2013-01-24 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

Open Access i DiVA

fulltext(364 kB)178 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 364 kBChecksumma SHA-512
af99cf64580928d622ac944741878152808cfda4c7147827e71e4bbba155ac9044e692b6f4c6a4a05f44514ae3d503c2f41fb8b8ff99cf00b649c395c7e0b11c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Tenhunen, Jyrki

Sök vidare i DiVA

Av författaren/redaktören
Tenhunen, Jyrki
Av organisationen
Anestesiologi och intensivvård
I samma tidskrift
Intensive Care Medicine
Anestesi och intensivvård

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 178 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 749 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf