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Evaluation of patients with cardiac amyloidosis using echocardiography, ECG and right heart catheterization
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för radiologi, onkologi och strålningsvetenskap, Enheten för nuklearmedicin och PET.
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2013 (engelsk)Inngår i: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 20, nr 1, s. 27-33Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aims:

To characterize patients with cardiac amyloidosis using echocardiography, electrocardiogram (ECG) and right heart catheterization (RHC).

Methods and results:

Fourteen patients with biopsy verified light chain or transthyretin cardiac amyloidosis were included. All patients had heart failure with markedly elevated NT-proBNP. Echocardiography demonstrated biventricular hypertrophy, left atrial enlargement and normal to slightly reduced left ventricular ejection fraction. Tissue Doppler septal e´ was low and median E/e´ was high. Within 6 months RHC was performed in eight of the patients. The restrictive filling pattern demonstrated by echocardiography corresponded well to median pulmonary wedge pressure (21 mmHg). Systolic pulmonary artery pressure (SPAP) was increased, whereas cardiac output and stroke volume were seen to be decreased with both methods. ECG demonstrated: low voltage (36%), abnormal R-progression (65%), ST-T abnormalities (71%) and high incidence of fibrillation (36%). In addition, a case report following the treatment of melphalan and dexamethasone is presented with improvement of hypertrophy, SPAP, left ventricular mass and e´.

Conclusion:

These findings should lead to a suspicion of cardiac amyloidosis and suggest further investigation.

sted, utgiver, år, opplag, sider
2013. Vol. 20, nr 1, s. 27-33
HSV kategori
Forskningsprogram
Kardiologi
Identifikatorer
URN: urn:nbn:se:uu:diva-196246DOI: 10.3109/13506129.2012.761967ISI: 000315187100005PubMedID: 23339421OAI: oai:DiVA.org:uu-196246DiVA, id: diva2:609535
Tilgjengelig fra: 2013-03-06 Laget: 2013-03-06 Sist oppdatert: 2017-12-06bibliografisk kontrollert

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Granstam, Sven-OlofRosengren, SaraKero, TanjaSörensen, JensFlachskampf, Frank AWikström, Gerhard

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Amyloid: Journal of Protein Folding Disorders

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