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The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Science for Life Laboratory, SciLifeLab.
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
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2013 (Engelska)Ingår i: Physiological Genomics, ISSN 1094-8341, E-ISSN 1531-2267, Vol. 45, nr 9, s. 367-376Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Carnitine palmitoyl-CoA transferase-1B is a mitochondrial enzyme in the fatty acid oxidation pathway. In a previous study, CPT1B was identified as differentially expressed in the hypothalamus of two lines of chickens established by long-term selection for high (HWS) or low (LWS) body weight. Mammals have three paralogs (CPT1a, b and c) while non-mammalian vertebrates only have two (CPT1A, B). CPT1A is expressed in liver and CPT1B in muscle. CPT1c is expressed in hypothalamus, where it regulates feeding and energy expenditure. We identified an intronic length polymorphism, fixed for different alleles in the two populations and mapped the hitherto missing CPT1B locus in the chicken genome assembly, to the distal tip of chromosome 1p. Based on molecular phylogeny and gene synteny we suggest that chicken CPT1B is pro-orthologous of the mammalian CPT1c. Chicken CPT1B was differentially expressed in both muscle and hypothalamus but in opposite directions: higher levels in hypothalamus but lower levels in muscle in the HWS than in the LWS line. Using an advanced inter-cross population of the lines, CPT1B expression was found to be influenced by a cis-acting expression quantitative trait locus in muscle. The increased expression in hypothalamus and reduced expression in muscle is consistent with an increased food intake in the HWS line and at the same time reduced fatty acid oxidation in muscle yielding a net accumulation of energy intake and storage. The altered expression of CPT1B in hypothalamus and peripheral tissue is likely to be a mechanism contributing to the remarkable difference between lines.

Ort, förlag, år, upplaga, sidor
2013. Vol. 45, nr 9, s. 367-376
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Klinisk medicin
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URN: urn:nbn:se:uu:diva-197716DOI: 10.1152/physiolgenomics.00078.2012ISI: 000318265700003PubMedID: 23512741OAI: oai:DiVA.org:uu-197716DiVA, id: diva2:613912
Tillgänglig från: 2013-04-02 Skapad: 2013-04-02 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Ring, HenrikHarun-Or-Rashid, MohammadWahlberg, PerAndersson, LeifHallböök, Finn

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Ring, HenrikHarun-Or-Rashid, MohammadWahlberg, PerAndersson, LeifHallböök, Finn
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Institutionen för neurovetenskapScience for Life Laboratory, SciLifeLabMedicinsk utvecklingsbiologiInstitutionen för immunologi, genetik och patologi
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