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Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
Vise andre og tillknytning
2014 (engelsk)Inngår i: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 134, nr 2, s. 426-432Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

INTRODUCTION:

We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.

MATERIALS AND METHODS:

39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.

RESULTS:

Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).

CONCLUSIONS:

It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

sted, utgiver, år, opplag, sider
2014. Vol. 134, nr 2, s. 426-432
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-230554DOI: 10.1016/j.thromres.2014.03.054ISI: 000341309200036PubMedID: 24745723OAI: oai:DiVA.org:uu-230554DiVA, id: diva2:740964
Tilgjengelig fra: 2014-08-26 Laget: 2014-08-26 Sist oppdatert: 2017-12-05bibliografisk kontrollert

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