Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitorVise andre og tillknytning
1997 (engelsk)Inngår i: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 40, nr 6, s. 898-902Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1‘ positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 Å resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1‘ and P2‘ side chains were transposed.
sted, utgiver, år, opplag, sider
1997. Vol. 40, nr 6, s. 898-902
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-51162DOI: 10.1021/jm960588dPubMedID: 9083478OAI: oai:DiVA.org:uu-51162DiVA, id: diva2:79071
2008-01-292008-01-292018-03-05bibliografisk kontrollert