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Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurologi. (neurology)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi.
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2015 (engelsk)Inngår i: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 6, artikkel-id 137Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Diffuse low-grade gliomas (DLGG) are slow-growing brain tumors that in spite of an indolent behavior at onset show a continuous expansion over time and inevitably transform into malignant gliomas. Extensive tumor resections may be performed with preservation of neurological function due to neuroplasticity that is induced by the slow tumor growth. However, DLGG prefer to migrate along subcortical pathways, and white matter plasticity is considerably more limited than gray matter plasticity. Whether signs of functional decompensating white matter that may be found as early as at disease presentation has not been systematically studied. Here, we examined 52 patients who presented with a DLGG at the time of radiological diagnosis. We found a significant correlation between neurological impairment and eloquent cortico-subcortical tumor localization, but not between neurological function and tumor volume. These results suggest that even small tumors invading white matter pathways may lack compensatory mechanisms for functional reorganization already at disease presentation.

sted, utgiver, år, opplag, sider
2015. Vol. 6, artikkel-id 137
Emneord [en]
low-grade gliomas; neurological function; professional situation; tumor volume; tumor location; brain plasticity; radiological diagnosis
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Identifikatorer
URN: urn:nbn:se:uu:diva-257072DOI: 10.3389/fneur.2015.00137ISI: 000363847800001PubMedID: 26113841OAI: oai:DiVA.org:uu-257072DiVA, id: diva2:828009
Tilgjengelig fra: 2015-06-29 Laget: 2015-06-29 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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Smits, AnjaZetterling, MariaFahlström, MarkusGrabowska, AnnaLarsson, Elna-MarieBerntsson, Shala Ghaderi

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