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The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Biokemisk struktur och funktion.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
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2015 (engelsk)Inngår i: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 76, nr 2, s. 514-518Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cytokines and chemokines regulate many functions in the body including the brain. The interactions between adipose tissue and the central nervous system (CNS) are important for the regulation of energy balance. CNS function is also influenced by age. The aim of the present study was to investigate the effects of body mass index (BMI) and age on cytokine and chemokine levels in cerebrospinal fluid. Cerebrospinal fluid samples (n=89) were collected from patients undergoing routine surgical procedures. The samples were analyzed using the multiplex proximity extension assay (PEA) in which 92 different cytokines are measured simultaneously using minute sample volume. We found no significant correlations between age and cytokine levels for any of the studied markers. In contrast, at a false discovery rate of 10%, 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1). This study reveals a clear effect of BMI on cytokine and chemokine levels in cerebrospinal fluid.

sted, utgiver, år, opplag, sider
2015. Vol. 76, nr 2, s. 514-518
Emneord [en]
Age; Body mass index; Cytokine; Human; Proximity extension assay (PEA); Cerebrospinal fluid
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Identifikatorer
URN: urn:nbn:se:uu:diva-259347DOI: 10.1016/j.cyto.2015.07.010ISI: 000364244400051PubMedID: 26188367OAI: oai:DiVA.org:uu-259347DiVA, id: diva2:843860
Forskningsfinansiär
VINNOVASwedish Research CouncilTilgjengelig fra: 2015-07-31 Laget: 2015-07-31 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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