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The role of complement factor C3 in lipid metabolism
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
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2015 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 67, no 1, p. 101-107Article, review/survey (Refereed) Published
Abstract [en]

Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism. The C3 fragment, C3a-desArg, functions as a hormone that has insulin-like effects and facilitates triglyceride metabolism. Adipose tissue produces and regulates the levels of complement components, which promotes generation of inflammatory initiators such as the anaphylatoxins C3a and C5a. The anaphylatoxins trigger a cyto/chemokine response in proportion to the amount of adipose tissue present, and induce inflammation and mediate metabolic effects such as insulin resistance. These observations support the concept that complement is an important participant in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity.

Place, publisher, year, edition, pages
2015. Vol. 67, no 1, p. 101-107
Keywords [en]
C3, C3a-desArg, Obesity, Metabolic syndrome (MetS), Apolipoproteins
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-261039DOI: 10.1016/j.molimm.2015.02.027ISI: 000357144100011PubMedID: 25746915OAI: oai:DiVA.org:uu-261039DiVA, id: diva2:850415
Available from: 2015-09-01 Created: 2015-08-28 Last updated: 2022-01-29Bibliographically approved

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Barbu, AndreeaLind, LarsEkdahl, Kristina NilssonNilsson, Bo

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