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MRI of neuronal ceroid lipofuscinosis: II. Postmortem MRI and histopathological study of the brain in 16 cases of neuronal ceroid lipofuscinosis of juvenile or late infantile type
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för onkologi, radiologi och klinisk immunologi. (RAD)
Vise andre og tillknytning
1997 (engelsk)Inngår i: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 39, nr 5, s. 371-7Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Postmortem MRI was carried out on the formalin-fixed brains of 14 patients with juvenile (JNCL) and two with late infantile neuronal ceroid lipofuscinosis, one of variant and the other of classical type. Two patients with JNCL had also undergone MRI during life. After MRI, specimens for histopathological analysis were taken from standard areas of the cerebral cortex, deep nuclei and white matter. The signal intensity of the periventricular white matter was usually higher than that of the peripheral white matter, a finding which correlated with the severe periventricular loss of myelin and gliosis observed histologically. The signal intensity was usually lower in the thalamus than in the putamen; in some patients the signal intensity of the thalamus was equal to or even lower than that of the white matter. However, myelin loss, gliosis, the storage process or neuronal loss in the thalamus did not correlate with the MRI findings. Since in one patient with JNCL the ante- and postmortem MRI did not differ basically, it appears probable that the periventricular changes detected in vivo on MRI are due to the severe loss of myelin and gliosis observed in this study. However, changes resulting from the fixation process must be considered, when postmortem and in vivo MRI are correlated.

sted, utgiver, år, opplag, sider
1997. Vol. 39, nr 5, s. 371-7
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URN: urn:nbn:se:uu:diva-57597DOI: 10.1007/s002340050427PubMedID: 9189886OAI: oai:DiVA.org:uu-57597DiVA, id: diva2:85506
Tilgjengelig fra: 2008-10-17 Laget: 2008-10-17 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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