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A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
Univ Gothenburg, Krefting Res Ctr, Dept Internal Med & Clin Nutr, SE-40530 Gothenburg, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, OLIN Unit, Occupat & Environm,Med, Umea, Sweden..
Umea Univ, Dept Clin Sci, OLIN Unit, Pediat, Umea, Sweden..
ThermoFisher Sci, Uppsala, Sweden..
ThermoFisher Sci, Uppsala, Sweden..
Vise andre og tillknytning
2015 (engelsk)Inngår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 26, nr 6, s. 557-563Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BackgroundAnimal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. MethodsA random sample of 696 children (11-12years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. ResultsOf 259 animal-sensitized children (0.1 kU(A)/l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. ConclusionsAmong schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.

sted, utgiver, år, opplag, sider
2015. Vol. 26, nr 6, s. 557-563
Emneord [en]
children, allergy, furry animals, allergen components, component-resolved diagnosis, asthma, rhinitis
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-264667DOI: 10.1111/pai.12422ISI: 000361476700011PubMedID: 26059105OAI: oai:DiVA.org:uu-264667DiVA, id: diva2:861325
Forskningsfinansiär
Swedish Heart Lung FoundationSwedish Asthma and Allergy AssociationSwedish Research CouncilTilgjengelig fra: 2015-10-16 Laget: 2015-10-15 Sist oppdatert: 2017-12-01bibliografisk kontrollert

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